header
Local cover image
Local cover image
Image from OpenLibrary

Role of aberrant growth factor expression and cytochrome P2D6 polymorphism in endocrine resistance in breast cancer using the real time superarray technique / Ibrahim Abdelaziz Ibrahim Malash ; Supervised Rabab Mohamed Gaafar , Sabry Mohamed Shaarawy , Osman Mohamed Mansour

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Ibrahim Abdelaziz Ibrahim Malash , 2014Description: 138 P. : charts ; 25cmOther title:
  • دراسة آليات المقاومه للعلاج الهرمونى لدى مريضات سرطان الثدى و امكانية استحداث طرق جديده للعلاج [Added title page title]
Subject(s): Online resources: Available additional physical forms:
  • Issued also as CD
Dissertation note: Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Oncology - Medical Summary: In an attempt to explore genetic factors behind resistance to tamoxifen and if possible targeting these factors or predicting response prior to therapy to avoid Tamoxifen in some patients who are expected to respond poorly to the drug. We prospectively studied the response to tamoxifen in braest cancer patients with measurable locally recurrent and / or metastatic hormone positive disease. We devided the patients into responsive and refractory groups according to response they showed to the drug. We studied the genetic profile of the groups to explore the effect of any genetc aberration that may be responsible for the degree of response to tamoxifen. Results showed that there is a statistically significant correlation between CYP2D6 mutations and resistance to tamoxifen P value = < 0.02
Tags from this library: No tags from this library for this title. Log in to add tags.
Star ratings
    Average rating: 0.0 (0 votes)
Holdings
Item type Current library Home library Call number Copy number Status Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.19.04.Ph.D.2014.Ib.R (Browse shelf(Opens below)) Not for loan 01010110064297000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.19.04.Ph.D.2014.Ib.R (Browse shelf(Opens below)) 64297.CD Not for loan 01020110064297000

Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Oncology - Medical

In an attempt to explore genetic factors behind resistance to tamoxifen and if possible targeting these factors or predicting response prior to therapy to avoid Tamoxifen in some patients who are expected to respond poorly to the drug. We prospectively studied the response to tamoxifen in braest cancer patients with measurable locally recurrent and / or metastatic hormone positive disease. We devided the patients into responsive and refractory groups according to response they showed to the drug. We studied the genetic profile of the groups to explore the effect of any genetc aberration that may be responsible for the degree of response to tamoxifen. Results showed that there is a statistically significant correlation between CYP2D6 mutations and resistance to tamoxifen P value = < 0.02

Issued also as CD

There are no comments on this title.

to post a comment.

Click on an image to view it in the image viewer

Local cover image