Formulation and biopharmaceutical evaluation of an anti schizophrenic drug /
Nermeen Adel Ahmed Elkasabgy
Formulation and biopharmaceutical evaluation of an anti schizophrenic drug / صياغة و تقييم بيوصيدلى لعقار معالج لفصام الشخصية Nermeen Adel Ahmed Elkasabgy ; Supervised Galal Elmahrouk , Mona Hassan Abouleinien - Cairo : Nermeen Adel Ahmed Elkasabgy , 2012 - 284 P. : charts , facsimiles ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics
Olanzapine is an effective antipsychotic drug used for the treatment of positive and negative symptoms of schizophrenia. But, it suffers from extensive first-pass metabolism in the liver to inactive metabolites, resulting in a poor oral bioavailability of nearly 60%. Therefore, to bypass this first-pass metabolism, olanzapine could be administered via other routes rather than the oral one e.g. rectal, injections, transdermal, etc
Antischizophrenic drug Olanzapine Solid lipid nanoparticles
Formulation and biopharmaceutical evaluation of an anti schizophrenic drug / صياغة و تقييم بيوصيدلى لعقار معالج لفصام الشخصية Nermeen Adel Ahmed Elkasabgy ; Supervised Galal Elmahrouk , Mona Hassan Abouleinien - Cairo : Nermeen Adel Ahmed Elkasabgy , 2012 - 284 P. : charts , facsimiles ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics
Olanzapine is an effective antipsychotic drug used for the treatment of positive and negative symptoms of schizophrenia. But, it suffers from extensive first-pass metabolism in the liver to inactive metabolites, resulting in a poor oral bioavailability of nearly 60%. Therefore, to bypass this first-pass metabolism, olanzapine could be administered via other routes rather than the oral one e.g. rectal, injections, transdermal, etc
Antischizophrenic drug Olanzapine Solid lipid nanoparticles