Modulating the balance between COX2 and PDE5 inhibitory activities of celecoxib analogues by adapting the nature of the core ring and peripheral rings substitution /
Mohammed Weam Ahmed
Modulating the balance between COX2 and PDE5 inhibitory activities of celecoxib analogues by adapting the nature of the core ring and peripheral rings substitution / تحوير التوازن التثبيطى لعقار السيليكوكسيب لانزيمى الكوكس - 2 والفو سفودايستراز - 5 عن طريق تكييف طبيعة الحلقة الأساسية ومستبدلات الحلقات الطرفية Mohammed Weam Ahmed ; Supervised Ashraf H. Abadi , Raimund Niess - Cairo : Mohammed Weam Ahmed , 2011 - 71Leaves : charts , facsimiles ; 30cm
Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry
The identification and characterization of inducible form of cyclooxygenase (COX2) in inflammatory cells in the early 1990s were the start of a race to the development of more selective nonsteroidal anti - inflammatory drugs (NSAIDs) , collectively known as coxibs , with reduced gastric - and nephrotoxicity compared to classical NSAIDs . However , coxibs were reported to increase the incidence of systemic hypertension and thromboembolic complications including myocardial infarction
Modulating the balance between COX2 and PDE5 inhibitory activities of celecoxib analogues by adapting the nature of the core ring and peripheral rings substitution / تحوير التوازن التثبيطى لعقار السيليكوكسيب لانزيمى الكوكس - 2 والفو سفودايستراز - 5 عن طريق تكييف طبيعة الحلقة الأساسية ومستبدلات الحلقات الطرفية Mohammed Weam Ahmed ; Supervised Ashraf H. Abadi , Raimund Niess - Cairo : Mohammed Weam Ahmed , 2011 - 71Leaves : charts , facsimiles ; 30cm
Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry
The identification and characterization of inducible form of cyclooxygenase (COX2) in inflammatory cells in the early 1990s were the start of a race to the development of more selective nonsteroidal anti - inflammatory drugs (NSAIDs) , collectively known as coxibs , with reduced gastric - and nephrotoxicity compared to classical NSAIDs . However , coxibs were reported to increase the incidence of systemic hypertension and thromboembolic complications including myocardial infarction