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Modulating the balance between COX2 and PDE5 inhibitory activities of celecoxib analogues by adapting the nature of the core ring and peripheral rings substitution / Mohammed Weam Ahmed ; Supervised Ashraf H. Abadi , Raimund Niess

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Mohammed Weam Ahmed , 2011Description: 71Leaves : charts , facsimiles ; 30cmOther title:
  • تحوير التوازن التثبيطى لعقار السيليكوكسيب لانزيمى الكوكس - 2 والفو سفودايستراز - 5 عن طريق تكييف طبيعة الحلقة الأساسية ومستبدلات الحلقات الطرفية [Added title page title]
Online resources: Dissertation note: Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry Summary: The identification and characterization of inducible form of cyclooxygenase (COX2) in inflammatory cells in the early 1990s were the start of a race to the development of more selective nonsteroidal anti - inflammatory drugs (NSAIDs) , collectively known as coxibs , with reduced gastric - and nephrotoxicity compared to classical NSAIDs . However , coxibs were reported to increase the incidence of systemic hypertension and thromboembolic complications including myocardial infarction
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Thesis Thesis قاعة الثقاقات الاجنبية - الدور الثالث المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.34.M.Sc.2011.Mo.M (Browse shelf(Opens below)) Not for loan 01010110060188000

Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry

The identification and characterization of inducible form of cyclooxygenase (COX2) in inflammatory cells in the early 1990s were the start of a race to the development of more selective nonsteroidal anti - inflammatory drugs (NSAIDs) , collectively known as coxibs , with reduced gastric - and nephrotoxicity compared to classical NSAIDs . However , coxibs were reported to increase the incidence of systemic hypertension and thromboembolic complications including myocardial infarction

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