Design of novel diarylheterocycles with potential kinase inhibitory and anticancer properties /
Rasha Mahmoud Hassan Rashied
Design of novel diarylheterocycles with potential kinase inhibitory and anticancer properties / تشييد مركبات داى أريل غير متجانسة الحلقة مثبطة لإنزيم الكيناز ومضادة للسرطان Rasha Mahmoud Hassan Rashied ; Supervised Ashraf H. Abadi , Raimund Niess - Cairo : Rasha Mahmoud Hassan Rashied , 2011 - 80Leaves : facsimiles ; 30cm
Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry
Previsouly reported , structurally diverse p38Ü MAP kinase inhibitors like pyridinyl-imidazole SB-203580 very often bind efficiently to their target , but suffer from potential toxicity due to the chelation of iron in cytochrome P450 by the imidazole or the pyridine ring which may result in hepatotoxicity and CNS adverse effects. Herein , we report the synthesis of novel 4,6-diaryl-2-oxo-( imino )-1,2-dihydropyridine-3-carbonitrile derivatives by multi-component reactions
Design of novel diarylheterocycles with potential kinase inhibitory and anticancer properties / تشييد مركبات داى أريل غير متجانسة الحلقة مثبطة لإنزيم الكيناز ومضادة للسرطان Rasha Mahmoud Hassan Rashied ; Supervised Ashraf H. Abadi , Raimund Niess - Cairo : Rasha Mahmoud Hassan Rashied , 2011 - 80Leaves : facsimiles ; 30cm
Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry
Previsouly reported , structurally diverse p38Ü MAP kinase inhibitors like pyridinyl-imidazole SB-203580 very often bind efficiently to their target , but suffer from potential toxicity due to the chelation of iron in cytochrome P450 by the imidazole or the pyridine ring which may result in hepatotoxicity and CNS adverse effects. Herein , we report the synthesis of novel 4,6-diaryl-2-oxo-( imino )-1,2-dihydropyridine-3-carbonitrile derivatives by multi-component reactions