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Design of novel diarylheterocycles with potential kinase inhibitory and anticancer properties / Rasha Mahmoud Hassan Rashied ; Supervised Ashraf H. Abadi , Raimund Niess

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Rasha Mahmoud Hassan Rashied , 2011Description: 80Leaves : facsimiles ; 30cmOther title:
  • تشييد مركبات داى أريل غير متجانسة الحلقة مثبطة لإنزيم الكيناز ومضادة للسرطان [Added title page title]
Online resources: Dissertation note: Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry Summary: Previsouly reported , structurally diverse p38Ü MAP kinase inhibitors like pyridinyl-imidazole SB-203580 very often bind efficiently to their target , but suffer from potential toxicity due to the chelation of iron in cytochrome P450 by the imidazole or the pyridine ring which may result in hepatotoxicity and CNS adverse effects. Herein , we report the synthesis of novel 4,6-diaryl-2-oxo-( imino )-1,2-dihydropyridine-3-carbonitrile derivatives by multi-component reactions
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Thesis Thesis قاعة الثقاقات الاجنبية - الدور الثالث المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.34.M.Sc.2011.Ra.D (Browse shelf(Opens below)) Not for loan 01010110060245000

Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry

Previsouly reported , structurally diverse p38Ü MAP kinase inhibitors like pyridinyl-imidazole SB-203580 very often bind efficiently to their target , but suffer from potential toxicity due to the chelation of iron in cytochrome P450 by the imidazole or the pyridine ring which may result in hepatotoxicity and CNS adverse effects. Herein , we report the synthesis of novel 4,6-diaryl-2-oxo-( imino )-1,2-dihydropyridine-3-carbonitrile derivatives by multi-component reactions

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