Transferosomes as delivery system for topical photodynamic therapy /
Doaa Ahmed Abdelfadeel
Transferosomes as delivery system for topical photodynamic therapy / الترانسفيروزومات كموصلات فى العلاج الضوئى الديناميكى Doaa Ahmed Abdelfadeel ; Supervised Kawser Nazmi Kassab , Maha Fadel Mohammed - Cairo : Doaa Ahmed Abdelfadeel , 2013 - 104 P. : photographs ; 25cm
Thesis (Ph.D.) - Cairo University - National Institute of Laser Enhanced Science - Department of Laser Application in Medical
The efficacy of transfersomes (flexible liposomes) as a novel technique for topical delivery of the hydrophilic tetra-anionic photodynamic sensitizer aluminum phthalocyanine tetrasulfonate (AIPcS4) was investigated, on mammalian fibroblasts and on Balb/c mice dorsal skin. AIPcS4 was loaded in transfersomes composed of phosphatidylcholine from soy bean and sodium deoxycholate as edge activator (5:1, 10:1, and 15:1 w/w, ratios), resulting in 110-, 160-, and 200-nm mean size vesicles with encapsulation efficiencies of 16, 25, and 30%, respectively
Aluminum phthalocyanine tetrasulfonate Topical photodynamic therapy Transfersomes
Transferosomes as delivery system for topical photodynamic therapy / الترانسفيروزومات كموصلات فى العلاج الضوئى الديناميكى Doaa Ahmed Abdelfadeel ; Supervised Kawser Nazmi Kassab , Maha Fadel Mohammed - Cairo : Doaa Ahmed Abdelfadeel , 2013 - 104 P. : photographs ; 25cm
Thesis (Ph.D.) - Cairo University - National Institute of Laser Enhanced Science - Department of Laser Application in Medical
The efficacy of transfersomes (flexible liposomes) as a novel technique for topical delivery of the hydrophilic tetra-anionic photodynamic sensitizer aluminum phthalocyanine tetrasulfonate (AIPcS4) was investigated, on mammalian fibroblasts and on Balb/c mice dorsal skin. AIPcS4 was loaded in transfersomes composed of phosphatidylcholine from soy bean and sodium deoxycholate as edge activator (5:1, 10:1, and 15:1 w/w, ratios), resulting in 110-, 160-, and 200-nm mean size vesicles with encapsulation efficiencies of 16, 25, and 30%, respectively
Aluminum phthalocyanine tetrasulfonate Topical photodynamic therapy Transfersomes