Cancer tumors growth factor polymorphisms in patients with systemic lupus erythematosus /
Dina Mohamed Mekawi Rabie
Cancer tumors growth factor polymorphisms in patients with systemic lupus erythematosus / الانواع الجينية لعامل النمو المبطن للاوعية الدموية فى مرضى الذئبة الحمراء Dina Mohamed Mekawi Rabie ; Supervised Laila Ahmed Rashed , Abeer Nabeel Mokbel , Nermeen Mohamed Hassan - Cairo : Dina Mohamed Mekawi Rabie , 2014 - 131 P. : charts ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Medicine- Department of Medical Biochemistry
Background: VEGF has a role in various diseases involving endothelial cells including lupus glomerulonephritis caused by immune complex deposition.Objectives: to study the association between VEGF polymorphism with susceptibility to SLE as well as lupus nephritis and its relation to VEGF protein level.subjects and methods:Acase control study involving 40 SLE patients without nephritis and 40 SLE patients with nephritis and 20 healthy controls. Polymerase chain reaction and restriction fragment lenght polymorphism(PCR- RFLP)methods were applied to detect polymorphism in VEGF promoter +405 and -460 and VEGF protein level was measured by ELISA.Results:. There was a significant difference in the VEGF 405 GG (52.5%) and VEGF TT 460 (57.5%) genotypes in lupus nephritis patients compared to the control subjects (35%) ,(45%) respectively
Cancer tumors Systemic Lupus Erythematosus Vascular endothelial growth
Cancer tumors growth factor polymorphisms in patients with systemic lupus erythematosus / الانواع الجينية لعامل النمو المبطن للاوعية الدموية فى مرضى الذئبة الحمراء Dina Mohamed Mekawi Rabie ; Supervised Laila Ahmed Rashed , Abeer Nabeel Mokbel , Nermeen Mohamed Hassan - Cairo : Dina Mohamed Mekawi Rabie , 2014 - 131 P. : charts ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Medicine- Department of Medical Biochemistry
Background: VEGF has a role in various diseases involving endothelial cells including lupus glomerulonephritis caused by immune complex deposition.Objectives: to study the association between VEGF polymorphism with susceptibility to SLE as well as lupus nephritis and its relation to VEGF protein level.subjects and methods:Acase control study involving 40 SLE patients without nephritis and 40 SLE patients with nephritis and 20 healthy controls. Polymerase chain reaction and restriction fragment lenght polymorphism(PCR- RFLP)methods were applied to detect polymorphism in VEGF promoter +405 and -460 and VEGF protein level was measured by ELISA.Results:. There was a significant difference in the VEGF 405 GG (52.5%) and VEGF TT 460 (57.5%) genotypes in lupus nephritis patients compared to the control subjects (35%) ,(45%) respectively
Cancer tumors Systemic Lupus Erythematosus Vascular endothelial growth