Study of a novel Nano - delivery system for topical application of folic acid /
Eman Samy Ibrahim Shalaby
Study of a novel Nano - delivery system for topical application of folic acid / استخدام تكنولوجيا النانو فى مستحضرات حمض الفوليك للاستخدام على الجلد Eman Samy Ibrahim Shalaby ; Supervised Mahmoud M. Ghorab , Hussein O. Ammar , Dina M. Mostafa - Cairo : Eman Samy Ibrahim Shalaby , 2014 - 197 P. : charts ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics
The aim of this thesis was to formulate and evaluate topically applied folic acid nanostructured lipid carriers (NLCs) to offer sustained antioxidant and antiaging effects. FA NLCS were prepared by hot high pressure homogenization. Encapsulation efficiency (EE), in vitro release, ex vivo permeation and skin targeting were evaluated. Characterization of selected formulations followed, in addition to stability and water occlusion. Further, histology and antioxidant potential were evaluated. Encapsulation efficiency exceeded 95%. Incorporation of oil into solid lipids causes reduced crystallinity and more imperfections in the crystal lattice providing high drug encapsulation. Formulations with 30% oil showed maximum skin targeting, water occlusion with high efficiency of hydration and antioxidant potential
Antioxidant Folic acid Topical delivery
Study of a novel Nano - delivery system for topical application of folic acid / استخدام تكنولوجيا النانو فى مستحضرات حمض الفوليك للاستخدام على الجلد Eman Samy Ibrahim Shalaby ; Supervised Mahmoud M. Ghorab , Hussein O. Ammar , Dina M. Mostafa - Cairo : Eman Samy Ibrahim Shalaby , 2014 - 197 P. : charts ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics
The aim of this thesis was to formulate and evaluate topically applied folic acid nanostructured lipid carriers (NLCs) to offer sustained antioxidant and antiaging effects. FA NLCS were prepared by hot high pressure homogenization. Encapsulation efficiency (EE), in vitro release, ex vivo permeation and skin targeting were evaluated. Characterization of selected formulations followed, in addition to stability and water occlusion. Further, histology and antioxidant potential were evaluated. Encapsulation efficiency exceeded 95%. Incorporation of oil into solid lipids causes reduced crystallinity and more imperfections in the crystal lattice providing high drug encapsulation. Formulations with 30% oil showed maximum skin targeting, water occlusion with high efficiency of hydration and antioxidant potential
Antioxidant Folic acid Topical delivery