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Study of a novel Nano - delivery system for topical application of folic acid / Eman Samy Ibrahim Shalaby ; Supervised Mahmoud M. Ghorab , Hussein O. Ammar , Dina M. Mostafa

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Eman Samy Ibrahim Shalaby , 2014Description: 197 P. : charts ; 25cmOther title:
  • استخدام تكنولوجيا النانو فى مستحضرات حمض الفوليك للاستخدام على الجلد [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics Summary: The aim of this thesis was to formulate and evaluate topically applied folic acid nanostructured lipid carriers (NLCs) to offer sustained antioxidant and antiaging effects. FA NLCS were prepared by hot high pressure homogenization. Encapsulation efficiency (EE), in vitro release, ex vivo permeation and skin targeting were evaluated. Characterization of selected formulations followed, in addition to stability and water occlusion. Further, histology and antioxidant potential were evaluated. Encapsulation efficiency exceeded 95%. Incorporation of oil into solid lipids causes reduced crystallinity and more imperfections in the crystal lattice providing high drug encapsulation. Formulations with 30% oil showed maximum skin targeting, water occlusion with high efficiency of hydration and antioxidant potential
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.08.M.Sc.2014.Em.S (Browse shelf(Opens below)) Not for loan 01010110064739000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.08.M.Sc.2014.Em.S (Browse shelf(Opens below)) 64739.CD Not for loan 01020110064739000

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics

The aim of this thesis was to formulate and evaluate topically applied folic acid nanostructured lipid carriers (NLCs) to offer sustained antioxidant and antiaging effects. FA NLCS were prepared by hot high pressure homogenization. Encapsulation efficiency (EE), in vitro release, ex vivo permeation and skin targeting were evaluated. Characterization of selected formulations followed, in addition to stability and water occlusion. Further, histology and antioxidant potential were evaluated. Encapsulation efficiency exceeded 95%. Incorporation of oil into solid lipids causes reduced crystallinity and more imperfections in the crystal lattice providing high drug encapsulation. Formulations with 30% oil showed maximum skin targeting, water occlusion with high efficiency of hydration and antioxidant potential

Issued also as CD

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