Evaluation of the therapeutic effect of whey proteins on the hepatotoxicity induced by paracetamol and alcohol Co-administration in rats /
Hesham Abdullah Helmy Eleiwa
Evaluation of the therapeutic effect of whey proteins on the hepatotoxicity induced by paracetamol and alcohol Co-administration in rats / تقييم بروتينات شرش اللبن لعلاج التسمم الكبدى المحدث بواسطة الباراسيتامول مع الكحول فى جزذان التجارب Hesham Abdullah Helmy Eleiwa ; Ezz Eldin Said Eldenshary , Somaia Ahmad Nada , Mohamed Farrag Elyamany - Cairo : Hesham Abdullah Helmy Eleiwa , 2014 - 174 P. : charts , facsimiles ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology
Hepatotoxicity induced by oral co-administration of paracetamol (APAP) (500 mg / kg) and alcohol (5 ml/ kg ) to each rat for two and four weeks .On the other hand, oral administration of whey protein isolate (WPI), alpha- lactalbumin (Ü-LA) and beta-lactoglobulin (Ý-LG) are used as therapeutic agents, in two dose levels (100 and 200 mg/kg) after induction of hepatotoxicity in both two and four weeks ,then liver tissue and blood sample collected. Oral administrated of APAP (500 mg / kg ) and alcohol (5 ml/ kg ) for two and four weeks increase in serum levels of alanine aminotransferase (ALT), and aspartate aminotransferase (AST). While, oral administration of WPI, Ü-LA and Ý-LG after APAP and alcohol resulted in reduction in serum AST and ALT activities , serum tumor necrosis factor- alpha (TNF- Ü) and hepatic lipid peroxidation marker malondialdehyde (MDA),while increase oxidative stress biomarkers (hepatic reduced glutathione (GSH) and superoxide dismutase (SOD)
Co-administration Hepatotoxicity Paracetamol
Evaluation of the therapeutic effect of whey proteins on the hepatotoxicity induced by paracetamol and alcohol Co-administration in rats / تقييم بروتينات شرش اللبن لعلاج التسمم الكبدى المحدث بواسطة الباراسيتامول مع الكحول فى جزذان التجارب Hesham Abdullah Helmy Eleiwa ; Ezz Eldin Said Eldenshary , Somaia Ahmad Nada , Mohamed Farrag Elyamany - Cairo : Hesham Abdullah Helmy Eleiwa , 2014 - 174 P. : charts , facsimiles ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology
Hepatotoxicity induced by oral co-administration of paracetamol (APAP) (500 mg / kg) and alcohol (5 ml/ kg ) to each rat for two and four weeks .On the other hand, oral administration of whey protein isolate (WPI), alpha- lactalbumin (Ü-LA) and beta-lactoglobulin (Ý-LG) are used as therapeutic agents, in two dose levels (100 and 200 mg/kg) after induction of hepatotoxicity in both two and four weeks ,then liver tissue and blood sample collected. Oral administrated of APAP (500 mg / kg ) and alcohol (5 ml/ kg ) for two and four weeks increase in serum levels of alanine aminotransferase (ALT), and aspartate aminotransferase (AST). While, oral administration of WPI, Ü-LA and Ý-LG after APAP and alcohol resulted in reduction in serum AST and ALT activities , serum tumor necrosis factor- alpha (TNF- Ü) and hepatic lipid peroxidation marker malondialdehyde (MDA),while increase oxidative stress biomarkers (hepatic reduced glutathione (GSH) and superoxide dismutase (SOD)
Co-administration Hepatotoxicity Paracetamol