Effect of insulin and phosphodiesterase type - 5 inhibitor (sildenafil) on aromatase level and uterine function in streptozotocin - induced diabetic female rats /
Safaa Mohammed Abdelwahab
Effect of insulin and phosphodiesterase type - 5 inhibitor (sildenafil) on aromatase level and uterine function in streptozotocin - induced diabetic female rats / تأثير الإنسولين و العقار المثبط لإنزيم فوسفوداى إستريز٥ (السيلدنافيل) على مستوى الأروماتيز و وظائف الرحم فى إناث الفئران المصابة بداء السكرى الناجم عن إعطاء عقار الإستربتوزوتوسين Safaa Mohammed Abdelwahab ; Supervised Alaa Eldin Amin Afifi , Hanan Abdelaziz Mubarak , Dina Sabry - Cairo : Safaa Mohammed Abdelwahab , 2014 - 141 P. : charts ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Physiology
Type I Diabetes Mellitus (DM) is associated with multiple reproductive abnormalities and hypoestrogenemia. This study aimed to assess the effect of diabetes on aromatase enzyme gene expression in ovarian and uterine tissues, as well as, its effect on the height of uterine contractions. Also, to identify the possible therapeutic effects of insulin and sildenafil on both the aromatase enzyme level and the height of uterine contractions. Fifty female rats divided into five groups, ten for each, Group I: normal control rats, Group II: untreated streptozotocin-induced diabetic rats, Group III: insulin - treated diabetic, Group IV: phosphodiesterase type 5 inhibitor (PDE5i)-sildenafil-treated diabetic rats and group V: Combined PDE5i (sildenafil) and insulin - treated diabetic rats. Fasting glucose, fasting insulin and estrogen were measured in serum. Aromatase enzyme gene expression was measured in both ovarian and uterine tissues. Peak heights of spontaneous uterine contractions were recorded
Aromatase enzyme Diabetes Uterine contraction
Effect of insulin and phosphodiesterase type - 5 inhibitor (sildenafil) on aromatase level and uterine function in streptozotocin - induced diabetic female rats / تأثير الإنسولين و العقار المثبط لإنزيم فوسفوداى إستريز٥ (السيلدنافيل) على مستوى الأروماتيز و وظائف الرحم فى إناث الفئران المصابة بداء السكرى الناجم عن إعطاء عقار الإستربتوزوتوسين Safaa Mohammed Abdelwahab ; Supervised Alaa Eldin Amin Afifi , Hanan Abdelaziz Mubarak , Dina Sabry - Cairo : Safaa Mohammed Abdelwahab , 2014 - 141 P. : charts ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Physiology
Type I Diabetes Mellitus (DM) is associated with multiple reproductive abnormalities and hypoestrogenemia. This study aimed to assess the effect of diabetes on aromatase enzyme gene expression in ovarian and uterine tissues, as well as, its effect on the height of uterine contractions. Also, to identify the possible therapeutic effects of insulin and sildenafil on both the aromatase enzyme level and the height of uterine contractions. Fifty female rats divided into five groups, ten for each, Group I: normal control rats, Group II: untreated streptozotocin-induced diabetic rats, Group III: insulin - treated diabetic, Group IV: phosphodiesterase type 5 inhibitor (PDE5i)-sildenafil-treated diabetic rats and group V: Combined PDE5i (sildenafil) and insulin - treated diabetic rats. Fasting glucose, fasting insulin and estrogen were measured in serum. Aromatase enzyme gene expression was measured in both ovarian and uterine tissues. Peak heights of spontaneous uterine contractions were recorded
Aromatase enzyme Diabetes Uterine contraction