Evaluation of p27-kip1, Her2/neu and ki-67 expression in breast invasive duct carcinoma /
Safinaz Talaat Anwar
Evaluation of p27-kip1, Her2/neu and ki-67 expression in breast invasive duct carcinoma / وعلاقتها فى حالات سرطانات قنوات الثدى p27, Her2 & Ki-67تقييم دور Safinaz Talaat Anwar ; Supervised Ahmed Mahmoud Abdelaziz , Samia Mohamed Gabal , Amira Mohamed Bassam - Cairo : Safinaz Talaat Anwar , 2015 - 151 P. : facsimiles ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pathology
p27 is a negative regulator of cell cycle, considered a tumor suppressor gene and belongs to a family of cyclin-dependent protein kinase inhibitors. The aim of this work is to study the value & importance of p27 expression as a potential prognostic marker in breast invasive duct carcinomas (NST).The examined cases were immunostained by p27 & correlated with established prognostic factors of breast carcinoma (tumor stage, grade, lymph node status, ER, PR, HER2/neu, Ki-67 index). The recorded results show statistically significant relationship between diminished p27 expression and aggressive parameters of the examined tumors. So our conclusion is that p27 is a potential prognostic & predictive marker and may play a role in designing an individually tailored cancer therapy
Breast invasive duct carcinoma Cell cycle Prognosis
Evaluation of p27-kip1, Her2/neu and ki-67 expression in breast invasive duct carcinoma / وعلاقتها فى حالات سرطانات قنوات الثدى p27, Her2 & Ki-67تقييم دور Safinaz Talaat Anwar ; Supervised Ahmed Mahmoud Abdelaziz , Samia Mohamed Gabal , Amira Mohamed Bassam - Cairo : Safinaz Talaat Anwar , 2015 - 151 P. : facsimiles ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pathology
p27 is a negative regulator of cell cycle, considered a tumor suppressor gene and belongs to a family of cyclin-dependent protein kinase inhibitors. The aim of this work is to study the value & importance of p27 expression as a potential prognostic marker in breast invasive duct carcinomas (NST).The examined cases were immunostained by p27 & correlated with established prognostic factors of breast carcinoma (tumor stage, grade, lymph node status, ER, PR, HER2/neu, Ki-67 index). The recorded results show statistically significant relationship between diminished p27 expression and aggressive parameters of the examined tumors. So our conclusion is that p27 is a potential prognostic & predictive marker and may play a role in designing an individually tailored cancer therapy
Breast invasive duct carcinoma Cell cycle Prognosis