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Evaluation of p27-kip1, Her2/neu and ki-67 expression in breast invasive duct carcinoma / Safinaz Talaat Anwar ; Supervised Ahmed Mahmoud Abdelaziz , Samia Mohamed Gabal , Amira Mohamed Bassam

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Safinaz Talaat Anwar , 2015Description: 151 P. : facsimiles ; 25cmOther title:
  • وعلاقتها فى حالات سرطانات قنوات الثدى p27, Her2 & Ki-67تقييم دور [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pathology Summary: p27 is a negative regulator of cell cycle, considered a tumor suppressor gene and belongs to a family of cyclin-dependent protein kinase inhibitors. The aim of this work is to study the value & importance of p27 expression as a potential prognostic marker in breast invasive duct carcinomas (NST).The examined cases were immunostained by p27 & correlated with established prognostic factors of breast carcinoma (tumor stage, grade, lymph node status, ER, PR, HER2/neu, Ki-67 index). The recorded results show statistically significant relationship between diminished p27 expression and aggressive parameters of the examined tumors. So our conclusion is that p27 is a potential prognostic & predictive marker and may play a role in designing an individually tailored cancer therapy
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.27.Ph.D.2015.Sa.E (Browse shelf(Opens below)) Not for loan 01010110067690000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.27.Ph.D.2015.Sa.E (Browse shelf(Opens below)) 67690.CD Not for loan 01020110067690000

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pathology

p27 is a negative regulator of cell cycle, considered a tumor suppressor gene and belongs to a family of cyclin-dependent protein kinase inhibitors. The aim of this work is to study the value & importance of p27 expression as a potential prognostic marker in breast invasive duct carcinomas (NST).The examined cases were immunostained by p27 & correlated with established prognostic factors of breast carcinoma (tumor stage, grade, lymph node status, ER, PR, HER2/neu, Ki-67 index). The recorded results show statistically significant relationship between diminished p27 expression and aggressive parameters of the examined tumors. So our conclusion is that p27 is a potential prognostic & predictive marker and may play a role in designing an individually tailored cancer therapy

Issued also as CD

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