Evaluation of survivin expression in breast cancer : Histopathological and immunohistochemical study /
Rabab Radi Gomaa Mahmoud
Evaluation of survivin expression in breast cancer : Histopathological and immunohistochemical study / تقييم التعبير عن "سرفيفين" فى سرطان الثدي : دراسة هستوباثولوجية و كميائية هستومناعية Rabab Radi Gomaa Mahmoud ; Supervised Solafa Ameen Alabyad , Hanan Hassan Mohammed , Rasha Ahmed Khairy - Cairo : Rabab Radi Gomaa Mahmoud , 2016 - 165 P. : charts , facsimiles ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pathology
Background: Breast cancer (BC) is the most common type of cancer among women world-wide and leading cause of cancer related deaths. As normal breast development is controlled by a balance between cell proliferation and apoptosis, and there is also strong evidence that tumor growth is not just a result of uncontrolled proliferation but also of reduced apoptosis. Tumor cells can acquire resistance to apoptosis by expression of certain anti apoptopic proteins called Inhibitors of Apoptosis Proteins (IAP). Survivin is the smallest IAP family member and has a dual activity as both an inhibitor of apoptosis and regulator of cell cycle. Objectives: Investigation of immunohistochemical expression of survivin in cases of female BC and correlation of this expression with the clinico-pathological aspects of the tumors. Materials and methods: Fifty formalin fixed paraffin embedded BC tissue sections were randomly collected. All the available data were collected from the patients reports. The paraffin blocks were sectioned and stained with hematoxylin & eosin stains for histologic evaluation. Additional sections were immunostained with survivin. Results: Nuclear survivin expression was detected in 66% of cases and it was associated with some of the negative prognostic factors although it didn't reach statistical significance (p-values were found to be higher than 0.05) where higher rate of survivin expression showed apparent direct association with IDC-NST histologic type, presence of insitu component, ER and PR negativity and high Ki-67 proliferation index as well as Her 2 enriched molecular subtype. Conclusion: Survivin expression is detected in 66% of breast carcinoma cases and is likely to be associated with poor prognosis making it a potential target for treatment
Apoptosis Breast cancer Immunohistochemistery
Evaluation of survivin expression in breast cancer : Histopathological and immunohistochemical study / تقييم التعبير عن "سرفيفين" فى سرطان الثدي : دراسة هستوباثولوجية و كميائية هستومناعية Rabab Radi Gomaa Mahmoud ; Supervised Solafa Ameen Alabyad , Hanan Hassan Mohammed , Rasha Ahmed Khairy - Cairo : Rabab Radi Gomaa Mahmoud , 2016 - 165 P. : charts , facsimiles ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pathology
Background: Breast cancer (BC) is the most common type of cancer among women world-wide and leading cause of cancer related deaths. As normal breast development is controlled by a balance between cell proliferation and apoptosis, and there is also strong evidence that tumor growth is not just a result of uncontrolled proliferation but also of reduced apoptosis. Tumor cells can acquire resistance to apoptosis by expression of certain anti apoptopic proteins called Inhibitors of Apoptosis Proteins (IAP). Survivin is the smallest IAP family member and has a dual activity as both an inhibitor of apoptosis and regulator of cell cycle. Objectives: Investigation of immunohistochemical expression of survivin in cases of female BC and correlation of this expression with the clinico-pathological aspects of the tumors. Materials and methods: Fifty formalin fixed paraffin embedded BC tissue sections were randomly collected. All the available data were collected from the patients reports. The paraffin blocks were sectioned and stained with hematoxylin & eosin stains for histologic evaluation. Additional sections were immunostained with survivin. Results: Nuclear survivin expression was detected in 66% of cases and it was associated with some of the negative prognostic factors although it didn't reach statistical significance (p-values were found to be higher than 0.05) where higher rate of survivin expression showed apparent direct association with IDC-NST histologic type, presence of insitu component, ER and PR negativity and high Ki-67 proliferation index as well as Her 2 enriched molecular subtype. Conclusion: Survivin expression is detected in 66% of breast carcinoma cases and is likely to be associated with poor prognosis making it a potential target for treatment
Apoptosis Breast cancer Immunohistochemistery