Evaluation of survivin expression in breast cancer : (Record no. 59581)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03125cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 170123s2016 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.27.M.Sc.2016.Ra.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Rabab Radi Gomaa Mahmoud |
| 245 10 - TITLE STATEMENT | |
| Title | Evaluation of survivin expression in breast cancer : |
| Remainder of title | Histopathological and immunohistochemical study / |
| Statement of responsibility, etc. | Rabab Radi Gomaa Mahmoud ; Supervised Solafa Ameen Alabyad , Hanan Hassan Mohammed , Rasha Ahmed Khairy |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تقييم التعبير عن "سرفيفين" فى سرطان الثدي : |
| Remainder of title | دراسة هستوباثولوجية و كميائية هستومناعية |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Rabab Radi Gomaa Mahmoud , |
| Date of publication, distribution, etc. | 2016 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 165 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pathology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Breast cancer (BC) is the most common type of cancer among women world-wide and leading cause of cancer related deaths. As normal breast development is controlled by a balance between cell proliferation and apoptosis, and there is also strong evidence that tumor growth is not just a result of uncontrolled proliferation but also of reduced apoptosis. Tumor cells can acquire resistance to apoptosis by expression of certain anti {u2013} apoptopic proteins called Inhibitors of Apoptosis Proteins (IAP). Survivin is the smallest IAP family member and has a dual activity as both an inhibitor of apoptosis and regulator of cell cycle. Objectives: Investigation of immunohistochemical expression of survivin in cases of female BC and correlation of this expression with the clinico-pathological aspects of the tumors. Materials and methods: Fifty formalin fixed paraffin embedded BC tissue sections were randomly collected. All the available data were collected from the patients{u2019} reports. The paraffin blocks were sectioned and stained with hematoxylin & eosin stains for histologic evaluation. Additional sections were immunostained with survivin. Results: Nuclear survivin expression was detected in 66% of cases and it was associated with some of the negative prognostic factors although it didn't reach statistical significance (p-values were found to be higher than 0.05) where higher rate of survivin expression showed apparent direct association with IDC-NST histologic type, presence of insitu component, ER and PR negativity and high Ki-67 proliferation index as well as Her 2 enriched molecular subtype. Conclusion: Survivin expression is detected in 66% of breast carcinoma cases and is likely to be associated with poor prognosis making it a potential target for treatment |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Apoptosis |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Breast cancer |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Immunohistochemistery |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hanan Hassan Mohammed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rasha Ahmed Khairy , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Solafa Ameen Alabyad , |
| Relator term | |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Enas |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.27.M.Sc.2016.Ra.E | 01010110070592000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.27.M.Sc.2016.Ra.E | 01020110070592000 | 22.09.2023 | CD - Rom | 70592.CD |