Study of the effect of linezolid alone and in combination with other antibiotics on methicillin resistant staphylococcus aureus electron microscope and time kill study /
Moushira Ali Badawi Masoud
Study of the effect of linezolid alone and in combination with other antibiotics on methicillin resistant staphylococcus aureus electron microscope and time kill study / دراسة بالميكروسكوب الإليكترونى و اختبار الوقت اللازم للقتل على ميكروب البكتيريا العنقودية المقاومة للمثيسيللين باستخدام مضاد اللاينيزوليد بمفرده و بالإضافة إلى مضادات حيويه اخرى Moushira Ali Badawi Masoud ; Supervised Hamida Mohamed Abdelhamid Gohar , Hoda Ahmed Yehia Abdalla , Nadia Mohammed Hassan Madany - Cairo : Moushira Ali Badawi Masoud , 2016 - 130 P. : facsimiles ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Microbiology and Immunology
The prevalence of methicillin resistant Staphyloccoccus. aureus (MRSA) strains has presented a new challenge in antimicrobial medication. Linezolid is a new drug with potent activity on Gram positive pathogens such as MRSA. The aim of the study was to investigate the in vitro activity of linezolid alone and in combination with imipenem, vancomycin or rifampicin to determine the most active therapy against MRSA strains linezolid may be combined with other antimicrobial agents in order to provide broad-spectrum coverage, prevent the emergence of resistant mutants, and obtain a synergy between both antimicrobial agents. Twenty clinical MRSA strains were isolated from patients admitted to inpatient departments and outpatient clinics of theodor bilharz research Institute. Standard strain MRSA ATCC 43300 was included as a control. The MICs of MRSA strains to linezolid, vancomycin, imipenem and rifampicin were evaluated using E test. Time kill curve experiments were used to assess the in vitro activity of linezolid (at 8x MIC) alone and in combination with imipenem (at 32x MIC), vancomycin or rifampicin (at 8x MIC). Scanning and transmission electron microscopy were performed to compare bacterial morphological alterations owing to the different combinations
Imipenem Linezolid MRSA
Study of the effect of linezolid alone and in combination with other antibiotics on methicillin resistant staphylococcus aureus electron microscope and time kill study / دراسة بالميكروسكوب الإليكترونى و اختبار الوقت اللازم للقتل على ميكروب البكتيريا العنقودية المقاومة للمثيسيللين باستخدام مضاد اللاينيزوليد بمفرده و بالإضافة إلى مضادات حيويه اخرى Moushira Ali Badawi Masoud ; Supervised Hamida Mohamed Abdelhamid Gohar , Hoda Ahmed Yehia Abdalla , Nadia Mohammed Hassan Madany - Cairo : Moushira Ali Badawi Masoud , 2016 - 130 P. : facsimiles ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Microbiology and Immunology
The prevalence of methicillin resistant Staphyloccoccus. aureus (MRSA) strains has presented a new challenge in antimicrobial medication. Linezolid is a new drug with potent activity on Gram positive pathogens such as MRSA. The aim of the study was to investigate the in vitro activity of linezolid alone and in combination with imipenem, vancomycin or rifampicin to determine the most active therapy against MRSA strains linezolid may be combined with other antimicrobial agents in order to provide broad-spectrum coverage, prevent the emergence of resistant mutants, and obtain a synergy between both antimicrobial agents. Twenty clinical MRSA strains were isolated from patients admitted to inpatient departments and outpatient clinics of theodor bilharz research Institute. Standard strain MRSA ATCC 43300 was included as a control. The MICs of MRSA strains to linezolid, vancomycin, imipenem and rifampicin were evaluated using E test. Time kill curve experiments were used to assess the in vitro activity of linezolid (at 8x MIC) alone and in combination with imipenem (at 32x MIC), vancomycin or rifampicin (at 8x MIC). Scanning and transmission electron microscopy were performed to compare bacterial morphological alterations owing to the different combinations
Imipenem Linezolid MRSA