Study the effect of nano and micro encapsulation of DNA vaccine model on its stability and immunogenicity /
Heba Ibrahim Mohamed Abdallah
Study the effect of nano and micro encapsulation of DNA vaccine model on its stability and immunogenicity / دراسة تأثير الصياغة على الثبات والقدرة المناعية لنموذج لقاح حامض الديكسيريبوز فى صورة حويصلات دقيقة او نانو مترية Heba Ibrahim Mohamed Abdallah ; Supervised Mahmoud Mohamed Ghorab , Aly Fahmy Mohamed - Cairo : Heba Ibrahim Mohamed Abdallah , 2017 - 172 P. : charts , facsimiles ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics
Herpes simplex virus type 2 (HSV-2) is a one of the most prevalent worldwide sexually transmitted infection. HSV-2 causes recurrent genital ulcers, neonatal herpes, and also, increases the risk for human immunodeficiency virus (HIV) acquisition. Many HSV-2 vaccines have been tested in humans, but were not consistently effective. In the present work we tried to produce a model vaccine for HSV-2 formulated in different formulae as an attempt for development of an effective prophylactic and therapeutic HSV-2 vaccine. Beta propiolactone (BPL) as a virus inactivant was compared with the conventional formalin (F). Gold and silver nanoparticles were prepared with different concentrations as a vaccine adjuvants. Also, calcium phosphate nanoparticles and bovine serum albumin nanoparticles were used as vaccine adjuvants . They were compared with currently used aluminum phosphate gel (alum) microparticles
DNA DNA vaccine model Nano and micro encapsulation
Study the effect of nano and micro encapsulation of DNA vaccine model on its stability and immunogenicity / دراسة تأثير الصياغة على الثبات والقدرة المناعية لنموذج لقاح حامض الديكسيريبوز فى صورة حويصلات دقيقة او نانو مترية Heba Ibrahim Mohamed Abdallah ; Supervised Mahmoud Mohamed Ghorab , Aly Fahmy Mohamed - Cairo : Heba Ibrahim Mohamed Abdallah , 2017 - 172 P. : charts , facsimiles ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics
Herpes simplex virus type 2 (HSV-2) is a one of the most prevalent worldwide sexually transmitted infection. HSV-2 causes recurrent genital ulcers, neonatal herpes, and also, increases the risk for human immunodeficiency virus (HIV) acquisition. Many HSV-2 vaccines have been tested in humans, but were not consistently effective. In the present work we tried to produce a model vaccine for HSV-2 formulated in different formulae as an attempt for development of an effective prophylactic and therapeutic HSV-2 vaccine. Beta propiolactone (BPL) as a virus inactivant was compared with the conventional formalin (F). Gold and silver nanoparticles were prepared with different concentrations as a vaccine adjuvants. Also, calcium phosphate nanoparticles and bovine serum albumin nanoparticles were used as vaccine adjuvants . They were compared with currently used aluminum phosphate gel (alum) microparticles
DNA DNA vaccine model Nano and micro encapsulation