Discovery of new selective antagonists for cell apoptosis inhibitor proteins as novel anticancer agents /
Ayat Gamal Ali Ahmed
Discovery of new selective antagonists for cell apoptosis inhibitor proteins as novel anticancer agents / إكتشاف مضادات إنتقائية جديدة للبروتينات المثبطة لعملية الموت الممنهج للخلايا كعوامل جديدة مضادة للسرطان Ayat Gamal Ali Ahmed ; Supervised Abdou Osman Abdelhamid , Mervat Elsayed Mohamed , Magda Fikry Mahmoud - Cairo : Ayat Gamal Ali Ahmed , 2017 - 175 P. : charts , facsimiles , photographs ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biochemistry
In this study, four new adamantane thiadiazole derivatives (ATDs) were designed and theoretically tested for their binding affinities to a model of an apoptosis inhibitor protein using molecular modeling. ATD-4, that showed the highest binding affinity, was synthesized, characterized and screened for its cytotoxic activity against different cancer cell lines as well as normal cell line using 5-fluorouracil as a reference organic drug. Inducing apoptosis in lung carcinoma cell line was studied by various biochemical and morphological methods. Results indicate that ATD-4 exerted its cytotoxic activity against A549 cells through the induction of the intrinsic (mitochondrial) apoptotic pathway
Adamantane thiadiazole derivatives Cytotoxicity Molecular modeling
Discovery of new selective antagonists for cell apoptosis inhibitor proteins as novel anticancer agents / إكتشاف مضادات إنتقائية جديدة للبروتينات المثبطة لعملية الموت الممنهج للخلايا كعوامل جديدة مضادة للسرطان Ayat Gamal Ali Ahmed ; Supervised Abdou Osman Abdelhamid , Mervat Elsayed Mohamed , Magda Fikry Mahmoud - Cairo : Ayat Gamal Ali Ahmed , 2017 - 175 P. : charts , facsimiles , photographs ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biochemistry
In this study, four new adamantane thiadiazole derivatives (ATDs) were designed and theoretically tested for their binding affinities to a model of an apoptosis inhibitor protein using molecular modeling. ATD-4, that showed the highest binding affinity, was synthesized, characterized and screened for its cytotoxic activity against different cancer cell lines as well as normal cell line using 5-fluorouracil as a reference organic drug. Inducing apoptosis in lung carcinoma cell line was studied by various biochemical and morphological methods. Results indicate that ATD-4 exerted its cytotoxic activity against A549 cells through the induction of the intrinsic (mitochondrial) apoptotic pathway
Adamantane thiadiazole derivatives Cytotoxicity Molecular modeling