Discovery of new selective antagonists for cell apoptosis inhibitor proteins as novel anticancer agents / (Record no. 64042)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02164cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031858.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 171216s2017 ua dho f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.02.Ph.D.2017.Ay.D |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Ayat Gamal Ali Ahmed |
| 245 10 - TITLE STATEMENT | |
| Title | Discovery of new selective antagonists for cell apoptosis inhibitor proteins as novel anticancer agents / |
| Statement of responsibility, etc. | Ayat Gamal Ali Ahmed ; Supervised Abdou Osman Abdelhamid , Mervat Elsayed Mohamed , Magda Fikry Mahmoud |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | إكتشاف مضادات إنتقائية جديدة للبروتينات المثبطة لعملية الموت الممنهج للخلايا كعوامل جديدة مضادة للسرطان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Ayat Gamal Ali Ahmed , |
| Date of publication, distribution, etc. | 2017 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 175 P. : |
| Other physical details | charts , facsimiles , photographs ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biochemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | In this study, four new adamantane thiadiazole derivatives (ATDs) were designed and theoretically tested for their binding affinities to a model of an apoptosis inhibitor protein using molecular modeling. ATD-4, that showed the highest binding affinity, was synthesized, characterized and screened for its cytotoxic activity against different cancer cell lines as well as normal cell line using 5-fluorouracil as a reference organic drug. Inducing apoptosis in lung carcinoma cell line was studied by various biochemical and morphological methods. Results indicate that ATD-4 exerted its cytotoxic activity against A549 cells through the induction of the intrinsic (mitochondrial) apoptotic pathway |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Adamantane thiadiazole derivatives |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Cytotoxicity |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Molecular modeling |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Abdou Osman Abdelhamid , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Magda Fikry Mahmoud , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mervat Elsayed Mohamed , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.02.Ph.D.2017.Ay.D | 01010110073719000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.12.02.Ph.D.2017.Ay.D | 01020110073719000 | 22.09.2023 | CD - Rom | 73719.CD |