Design , synthesis and biological evaluation of novel tamoxifen analogues /
Mirna Victor Azmy Ayad
Design , synthesis and biological evaluation of novel tamoxifen analogues / تصميم وتشييد وتقييم بيولوجي لمشتقات تاموكسيفين جديدة Mirna Victor Azmy Ayad ; Supervised Ashraf H. Abadi , Nermin Salah Ahmed - Cairo : Mirna Victor Azmy Ayad , 2017 - 94 Leaves : charts , facsimiles ; 30cm
Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry
Tamoxifen is the first SERM discovered to treat metastatic breasr cancer. Tamoxifen is metabolized to give 4-hydroxytamoxifen and 4-hydroxy N-desmethy1 Tamoxifen (Endoxifen) giving higher binding to Estrogen Receptor (ER) and higher potency in berast cancer calls. CYP2D6 and CYP3A4 are responsible for metabolizing Tamoxifen
CYP2D6 SERM Tamoxifen
Design , synthesis and biological evaluation of novel tamoxifen analogues / تصميم وتشييد وتقييم بيولوجي لمشتقات تاموكسيفين جديدة Mirna Victor Azmy Ayad ; Supervised Ashraf H. Abadi , Nermin Salah Ahmed - Cairo : Mirna Victor Azmy Ayad , 2017 - 94 Leaves : charts , facsimiles ; 30cm
Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry
Tamoxifen is the first SERM discovered to treat metastatic breasr cancer. Tamoxifen is metabolized to give 4-hydroxytamoxifen and 4-hydroxy N-desmethy1 Tamoxifen (Endoxifen) giving higher binding to Estrogen Receptor (ER) and higher potency in berast cancer calls. CYP2D6 and CYP3A4 are responsible for metabolizing Tamoxifen
CYP2D6 SERM Tamoxifen