Role and significance of DNA methylation in normal and abnormal hematopoiesis /
Manal Farouk Ahmed Abdelhafiz
Role and significance of DNA methylation in normal and abnormal hematopoiesis / دور و قيمة مثيلة الحمض النووى الديؤكسى ريبوزى فى تكوين الدم الطبيعى و الغير طبيعى Manal Farouk Ahmed Abdelhafiz ; Supervised Aisha Mostafa Abdelrahaman , Hoda Mohamed Abdelghani - Cairo : Manal Farouk Ahmed Abdelhafiz , 2006 - 160P : ill ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty Of Medicine - Department Of Clinical and Chemical Pathology
Data suggested that cancer appears to be a process that is fuelled both by genetic alterations and by epigenetic mechanisms Epigenetics refer to the study of changes in gene expression that can be mitotically inherited , but is not associated with the changes in the coding sequence of the affected genes The DNA methylation in the promoter regions is a powerful epigenetic mechanism for the suppression of gene activity Hypomethylation and hypermethylation are the two kinds of methylation defect that is observed in a wide variety of malignancies Hypomethylation is common in solid tumors such as metastatic hepatocellular cancer , in cervical cancer , prostate tumors , and also in hematological malignancies such as B - cell chronic lymphocytic leukemia A large number of genes involving fundamental cellular pathways may be affected by aberrant CpG island methylation in association with transcriptional silencing in virtually all tumor types
CpG islands DNA methylation Epigenetics in hematological malignancies Hypermethylation Hypomethylation
Role and significance of DNA methylation in normal and abnormal hematopoiesis / دور و قيمة مثيلة الحمض النووى الديؤكسى ريبوزى فى تكوين الدم الطبيعى و الغير طبيعى Manal Farouk Ahmed Abdelhafiz ; Supervised Aisha Mostafa Abdelrahaman , Hoda Mohamed Abdelghani - Cairo : Manal Farouk Ahmed Abdelhafiz , 2006 - 160P : ill ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty Of Medicine - Department Of Clinical and Chemical Pathology
Data suggested that cancer appears to be a process that is fuelled both by genetic alterations and by epigenetic mechanisms Epigenetics refer to the study of changes in gene expression that can be mitotically inherited , but is not associated with the changes in the coding sequence of the affected genes The DNA methylation in the promoter regions is a powerful epigenetic mechanism for the suppression of gene activity Hypomethylation and hypermethylation are the two kinds of methylation defect that is observed in a wide variety of malignancies Hypomethylation is common in solid tumors such as metastatic hepatocellular cancer , in cervical cancer , prostate tumors , and also in hematological malignancies such as B - cell chronic lymphocytic leukemia A large number of genes involving fundamental cellular pathways may be affected by aberrant CpG island methylation in association with transcriptional silencing in virtually all tumor types
CpG islands DNA methylation Epigenetics in hematological malignancies Hypermethylation Hypomethylation