Role and significance of DNA methylation in normal and abnormal hematopoiesis / (Record no. 72622)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 023630000a22003610004500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GICUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032321.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 070317s2006 ua a f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | Eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.07.M.Sc.2006.Ma.R |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Manal Farouk Ahmed Abdelhafiz |
| 245 10 - TITLE STATEMENT | |
| Title | Role and significance of DNA methylation in normal and abnormal hematopoiesis / |
| Statement of responsibility, etc. | Manal Farouk Ahmed Abdelhafiz ; Supervised Aisha Mostafa Abdelrahaman , Hoda Mohamed Abdelghani |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دور و قيمة مثيلة الحمض النووى الديؤكسى ريبوزى فى تكوين الدم الطبيعى و الغير طبيعى |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Manal Farouk Ahmed Abdelhafiz , |
| Date of publication, distribution, etc. | 2006 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 160P : |
| Other physical details | ill ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty Of Medicine - Department Of Clinical and Chemical Pathology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Data suggested that cancer appears to be a process that is fuelled both by genetic alterations and by epigenetic mechanisms Epigenetics refer to the study of changes in gene expression that can be mitotically inherited , but is not associated with the changes in the coding sequence of the affected genes The DNA methylation in the promoter regions is a powerful epigenetic mechanism for the suppression of gene activity Hypomethylation and hypermethylation are the two kinds of methylation defect that is observed in a wide variety of malignancies Hypomethylation is common in solid tumors such as metastatic hepatocellular cancer , in cervical cancer , prostate tumors , and also in hematological malignancies such as B - cell chronic lymphocytic leukemia A large number of genes involving fundamental cellular pathways may be affected by aberrant CpG island methylation in association with transcriptional silencing in virtually all tumor types |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | CpG islands |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | DNA methylation |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Epigenetics in hematological malignancies |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Hypermethylation |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Hypomethylation |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Aisha Mostafa Abdelrahaman , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hoda Mohamed Abdelghani , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Enas |
| Reviser | cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Mustafa |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.07.M.Sc.2006.Ma.R | 01010110046624000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.07.M.Sc.2006.Ma.R | 01020110046624000 | 22.09.2023 | CD - Rom | 46624.CD |