Assessment of some medicinal plants for treatment of obesity /
Riham Adel Elshiekh
Assessment of some medicinal plants for treatment of obesity / تقييم بعض النباتات الطبية لعلاج السمنة Riham Adel Elshiekh ; Supervised Mohamed S. Hifnawy , Essam A. Abdelsattar , Dalia A. Almahdy - Cairo : Riham Adel Elshiekh , 2019 - 195 P. : charts , facsimiles ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacognosy
The total methanolic and aqueous extracts of five plants (viz: Caralluma quadrangula, Caralluma tuberculata, Hibiscus shizopetalous, Hibiscus sabdariffa (white variety) and Solenostemma argel) were tested for their inhibitory activity against pancreatic lipase, Ü-amylase and Ü-glucosidase enzymes, along with their anti-oxidant potential via two different complementary methods; DPPH (1, 1-Diphenyl-2-picrylhydrazyl) radical scavenging activity and iron reducing power assays. The plants extracts were also estimated quantitatively for their total phenolic, flavonoid, tannin and steroidal contents. The results showed that Solenostemma argel was the most active among the selected plants. An optimized extraction method was developed for S. argel based on its enzyme inhibitory activity to ensure maximum biological activity. The methylene chloride and n-butanol fractions, in addition to, seven isolated compounds viz: sterols, pregnane glycoside and flavonoid aglycones and glycosides from S. argel were further evaluated. In-vivo biological study revealed that S. argel is a promising Egyptian natural drug, rich in pregnane glycosides, and could be considered a new therapeutic candidate targeting obesity. The ethanolic extract was also standardized using LCMS analysis for its content of stemmoside C
Solenostemma argel Ü-Amylase Ü-Glucosidase
Assessment of some medicinal plants for treatment of obesity / تقييم بعض النباتات الطبية لعلاج السمنة Riham Adel Elshiekh ; Supervised Mohamed S. Hifnawy , Essam A. Abdelsattar , Dalia A. Almahdy - Cairo : Riham Adel Elshiekh , 2019 - 195 P. : charts , facsimiles ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacognosy
The total methanolic and aqueous extracts of five plants (viz: Caralluma quadrangula, Caralluma tuberculata, Hibiscus shizopetalous, Hibiscus sabdariffa (white variety) and Solenostemma argel) were tested for their inhibitory activity against pancreatic lipase, Ü-amylase and Ü-glucosidase enzymes, along with their anti-oxidant potential via two different complementary methods; DPPH (1, 1-Diphenyl-2-picrylhydrazyl) radical scavenging activity and iron reducing power assays. The plants extracts were also estimated quantitatively for their total phenolic, flavonoid, tannin and steroidal contents. The results showed that Solenostemma argel was the most active among the selected plants. An optimized extraction method was developed for S. argel based on its enzyme inhibitory activity to ensure maximum biological activity. The methylene chloride and n-butanol fractions, in addition to, seven isolated compounds viz: sterols, pregnane glycoside and flavonoid aglycones and glycosides from S. argel were further evaluated. In-vivo biological study revealed that S. argel is a promising Egyptian natural drug, rich in pregnane glycosides, and could be considered a new therapeutic candidate targeting obesity. The ethanolic extract was also standardized using LCMS analysis for its content of stemmoside C
Solenostemma argel Ü-Amylase Ü-Glucosidase