Biochemical studies on the relation between tamoxifen, nano-nutrients and some bioactive components and gene expression in experimental breast cancer /
Dina Mostafa Mohammed Mohammed
Biochemical studies on the relation between tamoxifen, nano-nutrients and some bioactive components and gene expression in experimental breast cancer / دراسات بيوكيميائية عن العلاقة بين التاموكسفين: المغذيات النانو وبعض المركبات النشطة حيويا والتعبير الجينى فى سرطان الثدى التجريبي Dina Mostafa Mohammed Mohammed ; Supervised Abdou Osman Abdelhamid , Afaf Ezzat Abbas - Cairo : Dina Mostafa Mohammed Mohammed , 2020 - 289 P. : charts , facsimiles ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biochemistry
This work had been carried out to study converting drug (Tamoxifen), some nutrients (yeast) and bioactive compounds (Silymarin and Isoflavone) to nanoparticles and study their different effects in nano and normal scale on gene expression. Encourage the use of nanotechnology to limit the development and spread of breast cancer and the inhibitory effect of them on development of toxic material of mammary tumor for 180 days against with a single oral dose of (25 mg/kg) 7,12-dimethylbenz[a]anthracene (DMBA) in female rats. The body weight and food consumption will be examined. Upon the completion of the study, the histopathological studies on the breast tissues will be performed. The therapeutic and protective effects of these compounds in nano and normal scale will be evaluated using the appropriate parameters to determine the level of several chemicals related to oxidative damage (8-OHdG, Lipid Peroxide, TAC), Apoptosis, Plasma Estrogen and ErbB-2 in the blood samples. Also, the gene expression of ErbB-2 will be investigated in the blood samples. Finally, all the experimental results evaluated, tabulated and statistically analyzed. In conclusion, Breast cancer is highly curable if diagnosed with nutrients or medications whether in their normal or nano particles form at an early stage
Bioactive Components Breast Cancer Experimental Rats
Biochemical studies on the relation between tamoxifen, nano-nutrients and some bioactive components and gene expression in experimental breast cancer / دراسات بيوكيميائية عن العلاقة بين التاموكسفين: المغذيات النانو وبعض المركبات النشطة حيويا والتعبير الجينى فى سرطان الثدى التجريبي Dina Mostafa Mohammed Mohammed ; Supervised Abdou Osman Abdelhamid , Afaf Ezzat Abbas - Cairo : Dina Mostafa Mohammed Mohammed , 2020 - 289 P. : charts , facsimiles ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biochemistry
This work had been carried out to study converting drug (Tamoxifen), some nutrients (yeast) and bioactive compounds (Silymarin and Isoflavone) to nanoparticles and study their different effects in nano and normal scale on gene expression. Encourage the use of nanotechnology to limit the development and spread of breast cancer and the inhibitory effect of them on development of toxic material of mammary tumor for 180 days against with a single oral dose of (25 mg/kg) 7,12-dimethylbenz[a]anthracene (DMBA) in female rats. The body weight and food consumption will be examined. Upon the completion of the study, the histopathological studies on the breast tissues will be performed. The therapeutic and protective effects of these compounds in nano and normal scale will be evaluated using the appropriate parameters to determine the level of several chemicals related to oxidative damage (8-OHdG, Lipid Peroxide, TAC), Apoptosis, Plasma Estrogen and ErbB-2 in the blood samples. Also, the gene expression of ErbB-2 will be investigated in the blood samples. Finally, all the experimental results evaluated, tabulated and statistically analyzed. In conclusion, Breast cancer is highly curable if diagnosed with nutrients or medications whether in their normal or nano particles form at an early stage
Bioactive Components Breast Cancer Experimental Rats