Formulation and dvaluation of a low dissolution drug in soft gelatin capsules with solubilized and emulsified core adjuvants /
Abdalwali Ahmad Saif Hameed
Formulation and dvaluation of a low dissolution drug in soft gelatin capsules with solubilized and emulsified core adjuvants / صياغة وتقييم الكبسولات الجيلاتينيه الرخوة لعقار شحيح الاذابه فى سواغ مذابه ومستحلبه Abdalwali Ahmad Saif Hameed ; Supervised Mohamed Sayed Ahmed ElSamaligy , Omaima Naeem El Gazayerly - Cairo : Abdalwali Ahmad Saif Hameed , 2005 - 229p : ill ; 30cm
Thesis (M.Sc.) - Cairo University - Faculty Of Pharmacy - Department Of Pharmaceutics
Many drugs have limited bioavailability due to either the influence of the physiological factors associated with the structure and function of GI tract , or the physicochemical properties of the drug and dosage form factorsAs the drug should be soluble to be absorbed , one of the methods to increase the drug availability is to deliver it in solution dosage formMany of the old drugs and most of the outcome new molecules have limited solubilityThe need to manipulate drug's poor solubility is essential to reach the desired solution concentrationSolubilization methods are : cosolvency , micellar solubilization , complexation , pH control , hydrotropy and solid dispersion , chemical modification , crystal modification and particle size reduction
Capsules solubilized
Formulation and dvaluation of a low dissolution drug in soft gelatin capsules with solubilized and emulsified core adjuvants / صياغة وتقييم الكبسولات الجيلاتينيه الرخوة لعقار شحيح الاذابه فى سواغ مذابه ومستحلبه Abdalwali Ahmad Saif Hameed ; Supervised Mohamed Sayed Ahmed ElSamaligy , Omaima Naeem El Gazayerly - Cairo : Abdalwali Ahmad Saif Hameed , 2005 - 229p : ill ; 30cm
Thesis (M.Sc.) - Cairo University - Faculty Of Pharmacy - Department Of Pharmaceutics
Many drugs have limited bioavailability due to either the influence of the physiological factors associated with the structure and function of GI tract , or the physicochemical properties of the drug and dosage form factorsAs the drug should be soluble to be absorbed , one of the methods to increase the drug availability is to deliver it in solution dosage formMany of the old drugs and most of the outcome new molecules have limited solubilityThe need to manipulate drug's poor solubility is essential to reach the desired solution concentrationSolubilization methods are : cosolvency , micellar solubilization , complexation , pH control , hydrotropy and solid dispersion , chemical modification , crystal modification and particle size reduction
Capsules solubilized