MARC details
| 000 -LEADER |
|---|
| fixed length control field |
05768namaa22004331i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
OSt |
| 005 - أخر تعامل مع التسجيلة |
|---|
| control field |
20241010152632.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
241001b2023 |||a|||f m||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloguing agency |
EG-GICUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GICUC |
| Modifying agency |
EG-GICUC |
| Description conventions |
rda |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| Language code of summary or abstract |
eng |
| -- |
ara |
| 049 ## - Acquisition Source |
|---|
| Acquisition Source |
Deposite |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
|---|
| Classification number |
615.19 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) |
|---|
| Classification number |
615.19 |
| Edition number |
21 |
| 097 ## - Degree |
|---|
| Degree |
Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Local Call Number |
Cai01.08.08.Ph.D.2023.Yo.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Authority record control number or standard number |
Yomna Ahmed Moussa Abdelrahman, |
| Preparation |
preparation. |
| 245 12 - TITLE STATEMENT |
|---|
| Title |
A pharmaceutical study on certain solid lipid nanoparticles |
| Statement of responsibility, etc. |
by Yomna Ahmed Moussa Abdelrahman ; supervision of Prof. Mohamed Ahmed EL Nabarawi, Prof. Dalia Abd El Rahman Attia , Prof. Mohamed Mohey Eldein Elmazar , Prof. Mahmoud Hassan Teaima |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
/ دراسة صيدلية علي بعض جزيئات الدهون الصلبة النانومترية |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
|---|
| Date of production, publication, distribution, manufacture, or copyright notice |
2023. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
314 pages : |
| Other physical details |
illustrations ; |
| Dimensions |
25 cm. + |
| Accompanying material |
CD. |
| 336 ## - CONTENT TYPE |
|---|
| Content type term |
text |
| Source |
rda content |
| 337 ## - MEDIA TYPE |
|---|
| Media type term |
Unmediated |
| Source |
rdamedia |
| 338 ## - CARRIER TYPE |
|---|
| Carrier type term |
volume |
| Source |
rdacarrier |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (Ph.D)-Cairo University, 2023. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
|---|
| Bibliography, etc. note |
Bibliography: pages 271-314. |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Green coffee bean extract (GCBE), derived from unroasted coffee beans, has garnered considerable attention in recent years due to its rich composition of bioactive compounds. The main active component of GCBE is chlorogenic acid (CGA), a potent polyphenol known for its various biological activities. GCBE has demonstrated promising effects in the management of several health conditions, including antiobesity, anticelluite, antioxidant, antihypertension, and anti- inflammatory. Furthermore, it has been examined for its repurposed use as anticancer in HCT116 (colon cell line), HepG2 (liver cell line) and A649 (lung cancer cell line).<br/>Despite the various health benefits of CGA. Previous studies proved that CGA has an overall limited intestinal absorption that involves an active efflux mechanism that results in low bioavailability of chlorogenic acid. So, it was necessitated to incorporate GCBE in a valid dosage form as until now there hasn’t been any approved FDA GCBE product in the market.<br/>Solid lipid nanoparticles (SLNs) have emerged as a promising nanocarrier system for the delivery of various therapeutics. As they offer several benefits such as controlled release, enhanced bioavailability, biocompatibility, and site-specific accumulation, which make them an attractive option for various applications. In addition, the ability to modulate the physicochemical properties of drug loaded SLNs, such as particle size, surface charge, and entrapment efficiency, allows the development of tailored drug delivery systems with controlled release capabilities.<br/>So, the aim of this work was to enhance the therapeutic effects of GCBE by loading GCBE into SLNs and assess its activity compared to non-formulated GCBE<br/> <br/><br/><br/>which can be achieved by screening and optimizing GCBE-SLNs using Plackett- Burman design and Box-Behnken design to reach optimized formula of GCBE- SLNs that was assessed for its absorption and topical applications including its repurposed application as an anticancer drug in vitro and in vivo, as well as its traditional application as an anticellulite drug using clinical study. |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
مستخلص حبوب القهوة الخضراء ، المستمد من حبوب القهوةغير المحمصة، لفت انتباها كبيرا في السنوات الأخيرة بسبب تركيبته الغنية من المركبات الحيوية. المكون النشط الرئيسي في مستخلص حبوب القهوة الخضراء هو حمض الكلوروجينيك، وهو مركب بوليفينولي قوي معروف بأنه له أنشطة حيوية متنوعة. أظهر مستخلص حبوب القهوة الخضراء تأثيرات مشجعة في علاج العديد من الحالات الصحية كمضاد للسمنة، ومكافح للسلوليت، ومضاد للأكسدة، ومضاد لارتفاع ضغط الدم، ومضاد للالتهاب.<br/>هدف الرساله كان تعزيز توصيل وقابلية امتصاص مستخلص حبوب القهوة الخضراء ، من خلال تحميل مستخلص حبوب القهوة الخضراء في جزيئات الدهون الصلبة النانومترية ثم دمجه في كريم مما يعد استراتيجية واعدة لتطوير علاج ناجح. فرضية هذا العمل أن حمل مستخلص حبوب القهوة الخضراء داخل جزيئات الدهون الصلبة النانومترية يمكن أن يحميه من التحلل، ويسهل إطلاقه المنظم، ويحسن قابلية امتصاصه عند التناول عن طريق الفم ويمكنه من التراكم النوعي في الأنسجة أو الخلايا المستهدفة عند التطبيق الموضعي، وبالتالي يتم تحسين إمكاناته العلاجية. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Issues CD |
Issues also as CD. |
| 546 ## - LANGUAGE NOTE |
|---|
| Text Language |
Text in English and abstract in Arabic & English. |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Pharmaceutics |
| Source of heading or term |
qrmak |
| 653 #0 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Solid lipid nanoparticles |
| -- |
Green coffee bean extract |
| -- |
Chlorogenic acid |
| -- |
Anticancer |
| -- |
Anticellulite |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mohamed Ahmed EL Nabarawi |
| Relator term |
thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Dalia Abd El Rahman Attia |
| Relator term |
thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mohamed Mohey Eldein Elmazar |
| Relator term |
thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mahmoud Hassan Teaima |
| Relator term |
thesis advisor. |
| 900 ## - Thesis Information |
|---|
| Grant date |
01-01-2023 |
| Supervisory body |
Mohamed Ahmed EL Nabarawi |
| -- |
Dalia Abd El Rahman Attia |
| -- |
Mohamed Mohey Eldein Elmazar |
| -- |
Mahmoud Hassan Teaima |
| Universities |
Cairo University |
| Faculties |
Faculty of Pharmacy |
| Department |
Department of Pharmaceutics and Industrial Pharmacy |
| 905 ## - Cataloger and Reviser Names |
|---|
| Cataloger Name |
Shimaa |
| Reviser Names |
Huda |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
| Edition |
21 |
| Suppress in OPAC |
No |
