The nuclear factor kappa b pathway among egyptian patients with behcet’s syndrome and its correlation with the disease activity / (Record no. 170362)
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| fixed length control field | 07849namaa22004451i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20250223033416.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250122s2024 |||a|||f m||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 616.3 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 616.3 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.11.18.Ph.D.2024.Mo.N |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Moustafa Ali Saad Ali Soliman, |
| Preparation | preparation. |
| 245 14 - TITLE STATEMENT | |
| Title | The nuclear factor kappa b pathway among egyptian patients with behcet’s syndrome and its correlation with the disease activity / |
| Statement of responsibility, etc. | by Moustafa Ali Saad Ali Soliman ; Supervised by Prof. Dr. Hala Ibrahem Elgendy, Prof. Dr. Olfat Gamil Shaker, Dr. Mervat Essam Behiry, Dr. Ahmed Hatem Laymouna. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | مسار العامل النووي كابا ب بين مرضى متلازمة بهجت المصريين وارتباطه بنشاط المرض / |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2024. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 95 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D)-Cairo University, 2024. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 200-250. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Behcet's syndrome (BS) is a variable-vessel vasculitis characterized by <br/>recurrent orogenital ulcerations, ocular inflammation, and other manifestations. <br/>Hyperactive innate immunity plays an integral role in the pathogenesis of BS. The <br/>nuclear factor kappa B (NFKB) pathway family is a family of intracellular <br/>transcriptional factors that operate inside the neutrophils and macrophages upon <br/>stimulation of Toll-Like Receptor 4. It is involved in regulating inflammatory <br/>responses including innate and adaptive immune responses. NFKB pathway has a <br/>prominent role in the pathogenesis of BS. The NFKB1 intronic single nucleotide <br/>polymorphism (SNP) (rs4648068) is an A>G intron SNP in the NFKB1 gene that <br/>is postulated to have a possible role in the pathogenesis of BS. Micro-ribonucleic <br/>acid-9 (miRNA-9) is a miRNA that acts as an important regulator in neoplastic, <br/>neuronal, and autoimmune diseases. miRNA-9 operates as a negative feedback <br/>loop on the NFKB pathway. We aimed to study the association between the <br/>NFKB1 A>G (rs4648068) SNP and BS in Egyptian patients, in comparison to <br/>healthy controls, and to correlate the presence of rs4648068 SNP with the different <br/>activity domains of the disease. Also, we aimed to assess the possible role of <br/>miRNA-9 in BS, in comparison to healthy controls, and different activity domains. <br/>Subjects and Methodology: <br/>After ethical committee approval (Faculty of Medicine, Cairo University, <br/>Egypt, code MD-228-2022), the International Study Group Criteria for Behçet <br/>Disease (ISBD) criteria was used to recruit 60 BS patients, and the activity of the <br/>disease was assessed using Behcet’s Disease Current Activity Form (BDCAF), and <br/>the Behcet Syndrome Activity Score (BSAS). Another 60 matched controls were <br/>recruited. DNA extraction was done followed by PCR amplification to detect the <br/>target SNP. Gene expression of miRNA-9 was assessed using real-time PCR. <br/>Relative quantitation was calculated against internal control specific for miRNA. <br/>Results: <br/>The GG genotype was significantly higher in BS versus controls (21.7% and <br/>5% respectively, p value=0.015). Also, the G allele was significantly higher in BS <br/>versus controls (43.3% and 30% respectively, p value=0.033). Of the whole <br/><br/><br/> <br/><br/> <br/><br/>2 <br/><br/> <br/><br/>activity domains, only arthralgia was found to be significantly correlated with <br/>rs4648068 SNP. <br/>Also, our results showed a mean miRNA-9 53.44 fold change among cases <br/>in comparison to control (p-value < 0.001). ROC analysis concluded a cutoff value <br/>of miRNA-9 fold change (FC= 1.035, p-value < 0.001) with 71.7% sensitivity and <br/>100% specificity to differentiate BS cases from controls. <br/>Conclusion: <br/>NFKB1 rs4648068 A>G SNP increases the risk of developing BS. Among <br/>patients with BS, the GG genotype is protective against developing arthralgia. <br/>There is no statistically significant relation between rs4648068 SNP and either <br/>other activity domains of BS or the different activity scores of the disease. Also, <br/>miRNA-9 is a possible diagnostic marker in BS cases and may help in <br/>discriminating BS cases from conditions with similar presentations in case of <br/>diagnostic doubt with a high level of statistical significance. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | متلازمة بهجت هي التهاب مناعي بالأوعية الدموية يتميز بقرح متكررة بالفم والمنطقة التناسلية مع التهاب بالعين ومظاهر أخرى.<br/>فرط المناعة الفطرية أمر أساسي في التسبب في متلازمة بهجت. عائلة مسار العامل النووي كابا ب هي عائلة من عوامل النسخ داخل الخلايا التي تعمل داخل الخلايا المتعادلة والخلايا الآكلة الكبيرة عند تحفيز مستقبل Toll-Like 4. كما تشارك في تنظيم الاستجابات الالتهابية بما في ذلك الاستجابات المناعية الفطرية والتكيفية. تمت دراسة مسار العامل النووي كابا ب سابقًا في متلازمة بهجت. تم اقتراض أن تعدد أشكال النوكليوتيدات المفردة ذو الرقم المرجعي rs4648068 يمكن أن يكون له دور في نشوء متلازمة بهجت.<br/>الرنا متناهي الصغر 9 هو نوع من الرنا متناهي الصغر والذي يعمل كمنظم مهم في أمراض الأورام والخلايا العصبية والمناعة الذاتية. يعمل الرنا متناهي الصغر9 كحلقة تغذية سلبية لكبح جماح مسار العامل النووي كابا ب.<br/>نهدف من خلال هذه الدراسة إلى دراسة الارتباط بين تعدد أشكال النوكليوتيدات المفردة ذو الرقم المرجعي rs4648068 ومتلازمة بهجت في المرضى المصريين، بالمقارنة مع العينات الضابطة، وربطه مع مظاهر النشاط المختلفة للمرض. أيضًا، نحن نهدف إلى تقييم الدور المحتمل لـلرنا متناهي الصغر 9 في متلازمة بهجت، مقارنةً بالعينات الضابطة وأيضا مقارنته مع مظاهر النشاط المختلفة.<br/>بعد موافقة لجنة القيم، تم دراسة 60 مريض بمتلازمة بهجت بالمقارنة مع 60 مشارك سليم صحيا. تم دراسة نشاط المرض بواسطة الاستبيانات المعتمدة لدراسته مثل (BDCAF) و (BSAS) .<br/>تم إجراء استخراج الحمض النووي متبوعًا بتقنية PCR للكشف عن تعدد أشكال النوكليوتيدات المفردة ذو الرقم المرجعي rs4648068. تم تقييم التعبير الجيني لـلرنا متناهي الصغر 9 باستخدام تقنية PCR أيضا. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Internal Medicine |
| Source of heading or term | qrmak |
| 653 #0 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Behcet syndrome |
| -- | SNPs |
| -- | NFKB |
| -- | rs4648068 |
| -- | SNP |
| -- | miRNA-9 |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hala Ibrahem Elgendy |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Olfat Gamil Shaker |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mervat Essam Behiry |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ahmed Hatem Laymouna |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2024 |
| Supervisory body | Hala Ibrahem Elgendy |
| -- | Olfat Gamil Shaker |
| -- | Mervat Essam Behiry |
| -- | Ahmed Hatem Laymouna |
| Universities | Cairo University |
| Faculties | Faculty of Medicine |
| Department | Department of Internal Medicine |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| Reviser Names | Huda |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 22.01.2025 | 90289 | Cai01.11.18.Ph.D.2024.Mo.N | 01010110090289000 | 22.01.2025 | 22.01.2025 | Thesis |