Comparative cytotoxicity of ifofosfamide and its glyconjugate; glufosfamide in HepG2 cells / (Record no. 48494)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02272cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 141130s2014 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.02.Ph.D.2014.Do.C |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Doaa Ezzat Said Ahmed |
| 245 10 - TITLE STATEMENT | |
| Title | Comparative cytotoxicity of ifofosfamide and its glyconjugate; glufosfamide in HepG2 cells / |
| Statement of responsibility, etc. | Doaa Ezzat Said Ahmed ; Supervised Amr Saad M. Elsayed , Hossam Mohammed Arfa , Farida Hassan Gad Allh |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | HepG2السمية الخلوية المقارنة ل الأيفوفوسفاميد و مشتقه الجلوفوسفاميد في خلايا سرطان الكبد |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Doaa Ezzat Said Ahmed , |
| Date of publication, distribution, etc. | 2014 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 237 P. : |
| Other physical details | charts ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Science- Department of Biochemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | This work has been carried out to assess the cytotoxic potential of glufosfamide (GLU) in a hepatocellular carcinoma cell line paradigm; namely (HepG2), in comparison to its parent aglycone ifosfamide (IFO). HepG2 cells were used for assessment of cell viability and apoptotic cell death using MTT technique and flowcytometric analysis, respectively. Cell lysate was prepared to determine Bcl2 and caspase-3 gene expression (by Real time PCR), caspase-9 enzyme content (by ELISA) and ATP concentration (by luciferease-luminescence assay technique). The current study was extrapolated to assess any possible hepatotoxicity for glufosfamide and its parent compound; ifosfamide. The biochemical test battery entailed assessment of liver transaminases activities, oxidant/anti-oxidant status as manifested by measurement of tissue GSH and MDA contents, and both catalase and SOD activities. Histopathological examination of liver sections was achieved to confirm hepatotoxicity |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Glufosfamide (GLU) |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | HepG2 |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Ifofosfamide (IFO) |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Amr Saad Mohamed Elsayed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Farida Hassan Gad Allh , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hossam Mohammed Arfa , |
| Relator term | |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Aml |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.02.Ph.D.2014.Do.C | 01010110064028000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.12.02.Ph.D.2014.Do.C | 01020110064028000 | 22.09.2023 | CD - Rom | 64028.CD |