MARC details
| 000 -LEADER |
|---|
| fixed length control field |
02630cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
150526s2014 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.11.07.Ph.D.2014.Wa.D |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Walaa Abdelfattah Atya Elkak |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Differential effects of monophosphoryl lipid A and cytokine cocktail as maturation stimuli of dendritic cells for immunotherapy / |
| Statement of responsibility, etc. |
Walaa Abdelfattah Atya Elkak ; Supervised Mervat Mohamed Saad Elansary , Mervat Mohamed Wagih Matter , Ayatallah Amir Nassef |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
و خليط السيتوكينات كمحفزات لتنشيط الخلايا الشجيرية المستخدمة فى العلاج المناعى A التأثيرات المختلفة للمونوفوسفورايل ليبيد |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Walaa Abdelfattah Atya Elkak , |
| Date of publication, distribution, etc. |
2014 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
140 P. : |
| Other physical details |
charts , facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Dendritic cells (DCs) are professional antigen-presenting cells, owing to their superior capacity for acquiring and processing antigens for presentation to T cells. Since dendritic cells were identified as master cells in the modulation of the immune response, a lot of effort has been made to bring their potential to the clinical setting. Dendritic cells - based vaccines are considered an attractive tool for cancer immunotherapy that aim to reset a patient{u2019}s immune system and thereby elicit anti-tumor responses in vivo. In general, generation of MDDC (monocyte derived DC) from monocytes is induced in the presence of GM - CSF and IL - 4, and a maturation stimulus is added to the culture. TNF - Ü is the most common cytokine used for activating DC and generating mature MDDC. A chemically modified Lipopoly-saccharide derivative, monophosphoryl lipid A (MPLA), is one of the promising toll like receptor (TLR) ligands. It has been safely used as an adjuvant in various vaccine trials in humans. In our study, we compared the effects of traditional cytokine coktail (TNF alpha + IL - 1Ý) and MPLA as different maturation stimuli on MDDC |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
DC vaccine |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Dendritic cells |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Immunotherapy |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Ayatallah Amir Nassef , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mervat Mohamed Saad Elansary , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mervat Mohamed Wagih Matter , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Samia |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
