MicroRNAs as predictive biomarkers to the response to IFN therapy in chronic HCV patients / (Record no. 53583)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02575cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031343.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 151128s2015 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.03.Ph.D.2015.Ze.M |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Zeinab Ahmed Nour |
| 245 10 - TITLE STATEMENT | |
| Title | MicroRNAs as predictive biomarkers to the response to IFN therapy in chronic HCV patients / |
| Statement of responsibility, etc. | Zeinab Ahmed Nour ; Supervised Yasser Hussein Nassar , Olfat Gamil Shaker , Samar Ali Marzouk |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | الحمض الريبونيوكليوتيدي الدقيق كمتنبئات دلالات حيوية للاستجابة للعلاج بالانترفيرون في مرضي الالتهاب الكبدي الوبائي "سي |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Zeinab Ahmed Nour , |
| Date of publication, distribution, etc. | 2015 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 111 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Medical Biochemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background&Aims: In this work we aim to measure the miRNAs (-122, miR-155, miR-199a, miR-483) fold changes in sera of HCV patients genotype 4 before receiving Peg-INFÜ and ribavarin treatment and to find the association between these microRNAs levels and HCV to be used as potential predictive factors to the response to treatment as well as new biomarkers for HCV patients. Results: A significant statistical difference between responders and non- responders to Peg-IFN therapy of HCV patients regarding the expression of miRNA-122 and miRNA-155. The miRNA-199a and miRNA-483 showed high specificity and sensitivity by ROC curve. Positive correlations have been found between miRNAs-122, -155, 199a and -483, with a very strong positive correlation between miRNAs-155 and -199a, as well as between miRNAs-483 and -199a. Conclusion: miRNA-122 and miRNA -155 can serve as a possible baseline predictors of response to PegINF/RBV therapy. The expression profile of serum miRNA-483 and miR-199a can serve as novel non-invasive biomarkers for the diagnosis of HCV infection as upregulated miRNA-483 and downregulated miRNA-199a in the serum. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | HCV |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | IFN therapy |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | MicroRNAs |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | OlfatGamil Shaker , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Samar Ali Marzouk , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Yasser Hussein Nassar , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Soheir |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.03.Ph.D.2015.Ze.M | 01010110066785000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.03.Ph.D.2015.Ze.M | 01020110066785000 | 22.09.2023 | CD - Rom | 66785.CD |