Comparative study on the therapeutic effect of atorvastatin and stem cells on amiodarone induced lung injury in male rat / (Record no. 56797)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 03659cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031518.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 160605s2016 ua h f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.16.Ph.D.2016.Sa.C |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Samaa Samir Ibrahim Kamar |
| 245 10 - TITLE STATEMENT | |
| Title | Comparative study on the therapeutic effect of atorvastatin and stem cells on amiodarone induced lung injury in male rat / |
| Statement of responsibility, etc. | Samaa Samir Ibrahim Kamar ; Supervised Gihan Ibrahim AboulFotouh , Maha Baligh Zickri , Hala Gabr Metwally |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة مقارنة على التأثير العلاجى لعقارالأتورفاستاتين و الخلايا الجذعية فى إصابة الرئة المستحدثة بالأميودارون فى ذكر الجرذ |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Samaa Samir Ibrahim Kamar , |
| Date of publication, distribution, etc. | 2016 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 212 P. : |
| Other physical details | facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Histology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | The present study aimed at investigating and comparing the possible therapeutic effect of atorvastatin (ator) and human adipose derived stem cells (hADSCs) on amiodarone (AM)-induced lung injury in albino rat. Thirty four adult male albino rats weighing 200 gm were divided into: Gp I (Control group) of 8 rats, 2 given saline, 2 given tween 80, 2 given saline and tween 80 and the last 2 injected with phosphate buffer saline and sacrificed with the corresponding experimental groups. Gp II (ator group) of 6 rats, each received 10 mg/kg ator dissolved in 0.5 ml of saline orally 6 d/ w for 4 ws. The rats were sacrificed 4 ws following the drug cessation. Gp III (AM group) of 8 rats, each received AM at a dose of 30 mg/kg orally 6 d/ w for 4 ws. 2 rats were sacrificed at the end of 4 ws for the confirmation of lung damage by examination. The other 6 rats were sacrificed 4 ws following the drug cessation. Gp IV (AM and ator group): 6 rats were given AM in the same dose, by the same route as in Gp III for the first 4 ws. Then, the animals were given ator in the same dose, by the same route as in Gp II for the next 4 ws. At the end of the 8 ws the rats were sacrificed. Gp V (AM and SCs group): 6 rats were given AM in the same dose, by the same route as in Gp III for 4 ws. Then, they were injected with 0.5 ml of cultured and labeled hADSCs suspended in PBS on 2 successive days in the tail vein following confirmation of lung injury. The rats were sacrificed 4 ws following stem cell therapy. Histological, histochemical, immunohistochemical, morphometric and statistical studies were performed. Group II revealed picture nearly similar to that of Gp I. Gp III revealed patchy distribution of variable parenchymal changes. Partially obliterated lumen of some bronchioles, occasionally completely distorted ones, few projections of the lining epithelium, detachment of some projections, shed cellular debris were seen and some of the lining cells constituted dark nuclei. Mononuclear aggregates were detected in the adventitia of bronchi extending to the lumen and between the bronchi compressing alveoli and alveolar sacs. Occasional bronchi were filled with multiple leucocytes |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Atorvastatin |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Human ADSCs |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Lung |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Gihan Ibrahim AboulFotouh , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hala Gabr Metwally , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Maha Baligh Zickri , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.16.Ph.D.2016.Sa.C | 01010110069262000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.16.Ph.D.2016.Sa.C | 01020110069262000 | 22.09.2023 | CD - Rom | 69262.CD |