MARC details
| 000 -LEADER |
|---|
| fixed length control field |
02135cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
160813s2016 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.08.05.M.Sc.2016.Mo.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mona Ahmed Gamal Eldein Teleb |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Synthesis and cytotoxic activity of certain benzopyrone derivatives / |
| Statement of responsibility, etc. |
Mona Ahmed Gamal Eldein Teleb ; Supervised Fatma A. Ragab , Amal A. M Eissa , Samar Hashem Fahem |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
تشييد بعض مشتقات البينزوبيرون كمضادات للسرطان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Mona Ahmed Gamal Eldein Teleb , |
| Date of publication, distribution, etc. |
2016 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
123 P. : |
| Other physical details |
charts , facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Cancer is the biggest killer of our lives, so there is steadily increasing research in the field of anticancer therapy over recent years. However, lack of selectivity of chemotherapeutic agents against cancerous cells is still a significant problem with the current chemotherapy. Thus, in this study, the thirty new coumarin derivatives were synthesized and tested for their in vitro cytotoxic activity against MCF-7 breast cancer cell line. The most active derivatives were further tested against 4 different cell lines (HCT-116, HepG-2, A549 and SGC-7901 cell lines). In vitro EGFR inhibition in human breast cancer cell line MCF-7 was carried also for the most active 6 compounds. Furthermore, docking studies were undertaken for some compounds to gain insight into the possible binding mode of these compounds with the binding site of EGFR enzyme which is involved in cell survival and proliferation |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Benzopyrone |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Cancer |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Synthesis and cytotoxic activity |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Amal A. M Eissa , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Fatma A. Ragab , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Samar Hashem Fahem , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Samah |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
