header
Image from OpenLibrary

Synthesis and cytotoxic activity of certain benzopyrone derivatives / Mona Ahmed Gamal Eldein Teleb ; Supervised Fatma A. Ragab , Amal A. M Eissa , Samar Hashem Fahem

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Mona Ahmed Gamal Eldein Teleb , 2016Description: 123 P. : charts , facsimiles ; 25cmOther title:
  • تشييد بعض مشتقات البينزوبيرون كمضادات للسرطان [Added title page title]
Subject(s): Available additional physical forms:
  • Issued also as CD
Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry Summary: Cancer is the biggest killer of our lives, so there is steadily increasing research in the field of anticancer therapy over recent years. However, lack of selectivity of chemotherapeutic agents against cancerous cells is still a significant problem with the current chemotherapy. Thus, in this study, the thirty new coumarin derivatives were synthesized and tested for their in vitro cytotoxic activity against MCF-7 breast cancer cell line. The most active derivatives were further tested against 4 different cell lines (HCT-116, HepG-2, A549 and SGC-7901 cell lines). In vitro EGFR inhibition in human breast cancer cell line MCF-7 was carried also for the most active 6 compounds. Furthermore, docking studies were undertaken for some compounds to gain insight into the possible binding mode of these compounds with the binding site of EGFR enzyme which is involved in cell survival and proliferation
Tags from this library: No tags from this library for this title. Log in to add tags.
Star ratings
    Average rating: 0.0 (0 votes)
Holdings
Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.05.M.Sc.2016.Mo.S (Browse shelf(Opens below)) Not for loan 01010110069548000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.05.M.Sc.2016.Mo.S (Browse shelf(Opens below)) 69548.CD Not for loan 01020110069548000

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry

Cancer is the biggest killer of our lives, so there is steadily increasing research in the field of anticancer therapy over recent years. However, lack of selectivity of chemotherapeutic agents against cancerous cells is still a significant problem with the current chemotherapy. Thus, in this study, the thirty new coumarin derivatives were synthesized and tested for their in vitro cytotoxic activity against MCF-7 breast cancer cell line. The most active derivatives were further tested against 4 different cell lines (HCT-116, HepG-2, A549 and SGC-7901 cell lines). In vitro EGFR inhibition in human breast cancer cell line MCF-7 was carried also for the most active 6 compounds. Furthermore, docking studies were undertaken for some compounds to gain insight into the possible binding mode of these compounds with the binding site of EGFR enzyme which is involved in cell survival and proliferation

Issued also as CD

There are no comments on this title.

to post a comment.