Pharmacokinetics of cefquinome in normal and diseased camels / (Record no. 58799)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03160cam a2200313 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 161127s2016 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.10.15.M.Sc.2016.Ay.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Ayman Yousry Ali Elhadaky |
| 245 10 - TITLE STATEMENT | |
| Title | Pharmacokinetics of cefquinome in normal and diseased camels / |
| Statement of responsibility, etc. | Ayman Yousry Ali Elhadaky ; Supervised Attia Hassan Atta , Hassan Elsayed Abdou Elmetwaly |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | المسار الحركي لعقار السيفكينوم في الإبل السليمة والمصابة |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Ayman Yousry Ali Elhadaky , |
| Date of publication, distribution, etc. | 2016 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 131 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Veterinary Medicine - Department of Veterinary Pharmacology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | The aim of this work is to evaluate the pharmacokinetics of cefquinome in camels and to compare its pharmacokinetics in apparently healthy and Trypanosoma evansi infected camels. A single dose of cefquinome was administered intravenously and intramuscularly at 1 mg/kg to two groups of camels with a 30 days washout period in-between. Group (1) included five normal she-camels and Group (2): included five Trypanosoma evansi naturally infected she-camels. Plasma concentrations of cefquinome were determined by HPLC-MS/MS assay. Cefquinome concentration vs. time data after IV and IM was best fitted to a two-compartment open model in normal and infected camels. Cefquinome mean values of area under concentration{u2013}time curve (AUC) were 15.37±1.06 og/ml.h for IV dose and 12.85±2.15 og/ml.h for IM dose. Distribution half-lives and elimination half-lives after IV dose were 0.14±0.04 h and 3.15±0.22 h and 1.42±0.11 h and 6.68±0.87 h for IM dose. The values of total body clearance (Cl ) and volume of tot distribution at steady state (V ) were 0.07±0 L/kg/h and 0.27±0.02 l/kg, respectively following intravenous ss injection. Following a single intramuscular injection of 1 mg cefquinome /kg.b.wt. in normal camels, The pharmacokinetics parameter revealed that the maximum serum concentration (C ) was 3.2±0.39 æg/ml max reached at maximum time (T ) at about 0.82±0.06 h, the absorption half-life [t ] was 0.26±0.03 hours, max 1/2ab the elimination half-life t was 6.68±0.87hours and bioavailability of 85.52±11.09 %. The present study 1/2Ý recommended that the intravenous and intramuscular injection of cefquinome is effective against, Streptococcus spp., staphylococci, Klebsiella spp., Pasteurella spp., Salmonella spp., enteric and systemic Escherichia coli. at a dose rate of 1mg/kg twice daily for the normal and the naturally infected camels with Trypanosoma evansi, which did not suffer from fever or parasitaemia |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | LC-MS/MS |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Pharmacokinetics |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Cefquinome |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Attia Hassan Atta , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hassan Elsayed Abdou Elmetwaly , |
| Relator term | |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Soheir |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.10.15.M.Sc.2016.Ay.P | 01010110070384000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.10.15.M.Sc.2016.Ay.P | 01020110070384000 | 22.09.2023 | CD - Rom | 70384.CD |