Thesis (M.Sc.) - Cairo University - Faculty of Veterinary Medicine - Department of Veterinary Pharmacology

The aim of this work is to evaluate the pharmacokinetics of cefquinome in camels and to compare its pharmacokinetics in apparently healthy and Trypanosoma evansi infected camels. A single dose of cefquinome was administered intravenously and intramuscularly at 1 mg/kg to two groups of camels with a 30 days washout period in-between. Group (1) included five normal she-camels and Group (2): included five Trypanosoma evansi naturally infected she-camels. Plasma concentrations of cefquinome were determined by HPLC-MS/MS assay. Cefquinome concentration vs. time data after IV and IM was best fitted to a two-compartment open model in normal and infected camels. Cefquinome mean values of area under concentration{u2013}time curve (AUC) were 15.37±1.06 og/ml.h for IV dose and 12.85±2.15 og/ml.h for IM dose. Distribution half-lives and elimination half-lives after IV dose were 0.14±0.04 h and 3.15±0.22 h and 1.42±0.11 h and 6.68±0.87 h for IM dose. The values of total body clearance (Cl ) and volume of tot distribution at steady state (V ) were 0.07±0 L/kg/h and 0.27±0.02 l/kg, respectively following intravenous ss injection. Following a single intramuscular injection of 1 mg cefquinome /kg.b.wt. in normal camels, The pharmacokinetics parameter revealed that the maximum serum concentration (C ) was 3.2±0.39 æg/ml max reached at maximum time (T ) at about 0.82±0.06 h, the absorption half-life [t ] was 0.26±0.03 hours, max 1/2ab the elimination half-life t was 6.68±0.87hours and bioavailability of 85.52±11.09 %. The present study 1/2Ý recommended that the intravenous and intramuscular injection of cefquinome is effective against, Streptococcus spp., staphylococci, Klebsiella spp., Pasteurella spp., Salmonella spp., enteric and systemic Escherichia coli. at a dose rate of 1mg/kg twice daily for the normal and the naturally infected camels with Trypanosoma evansi, which did not suffer from fever or parasitaemia

Issued also as CD