MARC details
| 000 -LEADER |
|---|
| fixed length control field |
03347cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
161227s2016 ua h f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
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| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
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| Holding library |
Deposite |
| 097 ## - Thesis Degree |
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| Thesis Level |
Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.08.08.Ph.D.2016.Do.I |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Doaa Hamed Abdelaziz Yousef Ali |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Investigating the combined effect of hepatitis C viral infection and the genetic polymorphisms on the Adverse events of methotrexate and 6-mercaptopurine in childhood acute lymphoblastic leukemia / |
| Statement of responsibility, etc. |
Doaa Hamed Abdelaziz Yousef Ali ; Supervised Nirmeen A. Sabry , Manal H. Elsayed , Ahmed S. Attia |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
{uFEA9}{uFEAD}{uFE8D}{uFEB3}{uFE94} {uFE97}{uFE84}{uFE9B}{uFEF4}{uFEAE} {uFE8D}{uFED7}{uFE98}{uFEAE}{uFE8D}{uFEE5} {uFE8D}{uFEDF}{uFE98}{uFECC}{uFEAA}{uFEA9} {uFE8D}{uFEDF}{uFEA0}{uFEF4}{uFEE8}{uFEF0} {uFE91}{uFECC}{uFEAA}{uFEED}{uFEEF} {uFE8D}{uFEFB}{uFEDF}{uFE98}{uFEEC}{uFE8E}{uFE8F} {uFE8D}{uFEDF}{uFEDC}{uFE92}{uFEAA}{uFEEF} {uFE8D}{uFEDF}{uFED4}{uFEF4}{uFEAE}{uFEED}{uFEB3}{uFEF0} ({uFEB3}{uFEF0}) {uFECB}{uFEE0}{uFEF0} {uFE8D}{uFEDF}{uFEE4}{uFEA8}{uFE8E}{uFEC1}{uFEAE} {uFE8D}{uFEDF}{uFEB4}{uFEE0}{uFE92}{uFEF4}{uFE94} {uFEDF}{uFECC}{uFED8}{uFE8E}{uFEAD} {uFE8D}{uFEDF}{uFEE4}{uFEF4}{uFE9C}{uFEEE}{uFE97}{uFEAE}{uFEF3}{uFEDC}{uFEB4}{uFEF4}{uFE96} {uFEED} ٦ ميرفكابتوبيورين فى الأطفال المصابين بسرطان الدم الليمفاوى الحاد |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Doaa Hamed Abdelaziz Yousef Ali , |
| Date of publication, distribution, etc. |
2016 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
159 P. : |
| Other physical details |
facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
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| Dissertation note |
Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Background: The aim of the present study is to determine the correlation of HCV infection and polymorphisms in different genes with toxicity of either MTX or 6-MP administered to children with ALL. Methods: A hundred children with low risk ALL who were treated according to the St. Jude Total therapy XV were recruited. The recruited children were receiving MTX and 6-MP during maintenance phase. Patients were excluded from the study if they had other types of leukemia. Genotyping analyses for the TPMT, MTHFR, and GST genes were performed using a combination of PCR and PCR-RFLP protocols. Relevant clinical data on adverse drug reactions were collected objectively (blinded to genotypes) from the patient medical records. Results: There was a significant correlation between the combined presence of HCV and TPMT*3B G460A gene polymorphisms and grade 2-4 AST hepatotoxicity (p < 0.04). The same observation was seen when comparing either the presence of HCV alone or the presence of the gene polymorphism alone. A significant association between the combined presence of HCV and MTHFR C677T polymorphism and grades 2-4 ALT, AST, and ALP hepatotoxicity was observed (p values < 0.001, 0.02 and 0.001 respectively). The presence of HCV infection had a significant negative effect on hepatic transaminases |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Genetic polymorphisms |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Hepatitis C |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Methotrexate |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Ahmed S. Attia , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Manal H. Elsayed , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Nirmeen A. Sabry , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Shaima |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
