Investigating the combined effect of hepatitis C viral infection and the genetic polymorphisms on the Adverse events of methotrexate and 6-mercaptopurine in childhood acute lymphoblastic leukemia / Doaa Hamed Abdelaziz Yousef Ali ; Supervised Nirmeen A. Sabry , Manal H. Elsayed , Ahmed S. Attia
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TextLanguage: English Publication details: Cairo : Doaa Hamed Abdelaziz Yousef Ali , 2016Description: 159 P. : facsimiles ; 25cmOther title: - {uFEA9}{uFEAD}{uFE8D}{uFEB3}{uFE94} {uFE97}{uFE84}{uFE9B}{uFEF4}{uFEAE} {uFE8D}{uFED7}{uFE98}{uFEAE}{uFE8D}{uFEE5} {uFE8D}{uFEDF}{uFE98}{uFECC}{uFEAA}{uFEA9} {uFE8D}{uFEDF}{uFEA0}{uFEF4}{uFEE8}{uFEF0} {uFE91}{uFECC}{uFEAA}{uFEED}{uFEEF} {uFE8D}{uFEFB}{uFEDF}{uFE98}{uFEEC}{uFE8E}{uFE8F} {uFE8D}{uFEDF}{uFEDC}{uFE92}{uFEAA}{uFEEF} {uFE8D}{uFEDF}{uFED4}{uFEF4}{uFEAE}{uFEED}{uFEB3}{uFEF0} ({uFEB3}{uFEF0}) {uFECB}{uFEE0}{uFEF0} {uFE8D}{uFEDF}{uFEE4}{uFEA8}{uFE8E}{uFEC1}{uFEAE} {uFE8D}{uFEDF}{uFEB4}{uFEE0}{uFE92}{uFEF4}{uFE94} {uFEDF}{uFECC}{uFED8}{uFE8E}{uFEAD} {uFE8D}{uFEDF}{uFEE4}{uFEF4}{uFE9C}{uFEEE}{uFE97}{uFEAE}{uFEF3}{uFEDC}{uFEB4}{uFEF4}{uFE96} {uFEED} ٦ ميرفكابتوبيورين فى الأطفال المصابين بسرطان الدم الليمفاوى الحاد [Added title page title]
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Thesis
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قاعة الرسائل الجامعية - الدور الاول | المكتبة المركزبة الجديدة - جامعة القاهرة | Cai01.08.08.Ph.D.2016.Do.I (Browse shelf(Opens below)) | Not for loan | 01010110070703000 | |||
CD - Rom
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مخـــزن الرســائل الجـــامعية - البدروم | المكتبة المركزبة الجديدة - جامعة القاهرة | Cai01.08.08.Ph.D.2016.Do.I (Browse shelf(Opens below)) | 70703.CD | Not for loan | 01020110070703000 |
Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics
Background: The aim of the present study is to determine the correlation of HCV infection and polymorphisms in different genes with toxicity of either MTX or 6-MP administered to children with ALL. Methods: A hundred children with low risk ALL who were treated according to the St. Jude Total therapy XV were recruited. The recruited children were receiving MTX and 6-MP during maintenance phase. Patients were excluded from the study if they had other types of leukemia. Genotyping analyses for the TPMT, MTHFR, and GST genes were performed using a combination of PCR and PCR-RFLP protocols. Relevant clinical data on adverse drug reactions were collected objectively (blinded to genotypes) from the patient medical records. Results: There was a significant correlation between the combined presence of HCV and TPMT*3B G460A gene polymorphisms and grade 2-4 AST hepatotoxicity (p < 0.04). The same observation was seen when comparing either the presence of HCV alone or the presence of the gene polymorphism alone. A significant association between the combined presence of HCV and MTHFR C677T polymorphism and grades 2-4 ALT, AST, and ALP hepatotoxicity was observed (p values < 0.001, 0.02 and 0.001 respectively). The presence of HCV infection had a significant negative effect on hepatic transaminases
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