MARC details
| 000 -LEADER |
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| fixed length control field |
03282cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
171118s2017 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
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| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
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| Holding library |
Deposite |
| 097 ## - Thesis Degree |
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| Thesis Level |
Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| Classification number |
Cai01.12.21.Ph.D.2017.Sh.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
Shimaa Ahmed Sadek |
| 245 10 - TITLE STATEMENT |
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| Title |
Evaluation of prospective ameliorative effect of red alga, Actinotrichia fragilis, on experimentally osteoarthritic rats / |
| Statement of responsibility, etc. |
Shimaa Ahmed Sadek ; Supervised Mohamed Marzouk Mohamed , Amel Mahmoud Soliman , Amany Ahmed Sayed |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
تقييم التأثير التحسيني المحتمل للطحلب الأحمر (أكتينوتريكيا فراجيليس) علي الجرذان المصابة بالتهاب مفاصل العظام التجريبى |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Shimaa Ahmed Sadek , |
| Date of publication, distribution, etc. |
2017 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
290 P. : |
| Other physical details |
charts , facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
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| Dissertation note |
Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Zoology |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
Osteoarthritis (OA) is a degenerative joint disease characterized by progression of articular cartilage destruction. Current treatment strategies for OA are effective for symptoms relief but recent findings have shown that their long term utilization is associated with adverse side effects. Thus, natural alternative treatment for the cessation of OA disease is urgently needed. Thereby, the aim of the present study was to evaluate the efficacy of Actinotrichia fragilis, a red marine alga, in the powder form (AFP, 200 mg/kg body weight) and gel form (AFG, 200 mg/kg body weight) for both preventive and curative purposes against osteoarthritis induced by ovariectomy in rats. The effectiveness of AFP and AFG was compared with glucosamine as a standard antiosteoarthritic drug. The chemical screening of AFP and AFG revealed the presence of various active constituents such as phenolic compounds and sulphated glycosaminoglycan (GAG). Furthermore, the present study revealed the presence of various amino acid contents in AFP and AFG. Additionally, the ongoing study disclosed that AFP or AFG is inflammatory-proteinase-oxidant inhibitor and considered to be safe according to the OECD toxicity test. The current results recorded significant increase in body and thymus weights and significant decrease in uterus and vaginal weights. Ovariectomy induced OA was assessed biochemically by the increase in the levels of serum CTX II, GAG, IL-1Ý, MMP-1, MMP-13, CTX II/PIINP ratio, TALP, total cholesterol and triglycerides. In addition, a decrease in serum PIINP and BALP activity was revealed in comparison with the sham group. Meanwhile, ovariectomy induced an oxidative stress, which evidenced by a significant increase in knee MDA, NO levels and SOD ratio as well as significant reduction in knee GSH, SOD, CAT, GPx and GR contents as compared to the corresponding values of sham group |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
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| Additional physical form available note |
Issued also as CD |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Osteoarthritis |
| 653 #4 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Actinotrichia fragilis |
| 653 #4 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Red algae |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Amany Ahmed Sayed , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Amel Mahmoud Soliman , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mohamed Marzouk Mohamed , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
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| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Shimaa |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
