MARC details
| 000 -LEADER |
|---|
| fixed length control field |
03018cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
180805s2017 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.11.18.Ph.D.2017.Ma.M |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mahmoud Sayed Zidan Abdelall |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Mitochondrial DNA microchimerism in kidney transplant recipients / |
| Statement of responsibility, etc. |
Mahmoud Sayed Zidan Abdelall ; Supervised Mohamed Gamal Eldin Saadi , May A. Hassaballa , Mervat Elansary |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
الكشف عن الخيمرية الدقيقة باستخدام الحامض النووى فى مستقبلى زراعة الكلى |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Mahmoud Sayed Zidan Abdelall , |
| Date of publication, distribution, etc. |
2017 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
123 P. : |
| Other physical details |
charts , facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Internal Medicine |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Microchimerism is the presence of a small number of cells that originate from another individual and are therefore genetically distinct from the cells of the host individual, microchimerism has been proposed to play a bene{uFB01}cial immunomodulatory role toward the development of donor-speci{uFB01}c hypo responsiveness and allograft acceptance. Objectives: In this study, a quantitative amplification refractory mutation system quantitative polymerase chain reaction (ARMS-qPCR) approach using mitochondrial (mtDNA) polymorphisms of the HVRs I{u2013}III of the D-loop region of mtDNA was used to detect donor-speci{uFB01}c microchimerism tracing circulating mtDNA molecules in peripheral mononuclear blood cells ( PBMCs ) of renal transplant recipients, and to correlate between the presence or absence of donor-speci{uFB01}c microchimerism and graft survival and function as measured using serum creatinine and creatinine clearance. Patients and methods: ARMS-qPCR approach using mitochondrial DNA polymorphisms was used to detects and quantitates donor-speci{uFB01}c microchimerism with correlatation with graft function. Results: Donor-specific mtDNA using ARMS-qPCR technique was detectable in 17 cases (85%) ranging from 0.001% to 1.67% with mean value of 0.3638±0.3981%. Microchimerism was associated with early better graft function in spite of no impact on later graft function. Conclusion: We successfully used a sensitive real-time ARMS-PCR method based on mitochondrial DNA to determine and quantitate the donor microchimerism in kidney transplant recipients. Microchimerism was detected after kidney transplantation and was associated with early better graft function inspite of no impact on later graft function |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Kidney transplant recipients |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Microchimerism |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Mitochondrial DNA |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
May Hassaballa , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mervat Elansary , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mohamed Gamal Eldin Saadi , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Samia |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
