MARC details
| 000 -LEADER |
|---|
| fixed length control field |
02349cam a2200313 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
190420s2018 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.08.09.M.Sc.2018.Ay.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Aya Mostafa Abdellatif Mohamed |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Effects of estrogen and angiotensin receptor blocker on cognitive impairment in ovariectomized rats / |
| Statement of responsibility, etc. |
Aya Mostafa Abdellatif Mohamed ; Supervised Mahmoud Mohamed Khattab , Noha Fawzy Hamed |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
تأثير الإستروجين و مقيد لمستقبل الأنجيوتنسين فى ضعف التعرف فى الجرذان مستأصلة المبيض |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Aya Mostafa Abdellatif Mohamed , |
| Date of publication, distribution, etc. |
2018 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
139 P. : |
| Other physical details |
charts , facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
The present study aimed to investigate the possible effects of treatment with telmisartan and 17Ý-estradiol (E2) alone or in combination on Alzheimer{u2019}s disease (AD) like symptoms induced by D-galactose administration to ovariectomized rats. Treatment with telmisartane and E2 alone or in combination improved animals{u2019} behavior assessed by morris water maze and novel object recognition tests, alleviated histopathological alterations and reduced the level of inflammatory biomarkers 2tumor necrosis factor-Ü (TNF-Ü) and interleukin-1Ý (IL-1Ý)3 as well as AD biomarkers 2amyloid beta 1-42 (AÝ1-42) and acetylcholine esterase (AchE)3. This was associated with modulation in renin angiotensin system (RAS) favoring alternative neuroprotective arm (ACE2/ Ang (1-7)/ Mas receptor axis). Moreover, combined therapy produced more pronounced reduction in inflammatory biomarkers as well as AD biomarkers and more modulation of RAS than usage of each drug alone. These findings suggest possible therapeutic options for protection and delay of AD neurotoxicity |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Alzheimer{u2019}s disease |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Estradiol |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Telmisartan |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mahmoud Mohamed Khattab , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Noha Fawzy Hamed , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Samia |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
