Effects of estrogen and angiotensin receptor blocker on cognitive impairment in ovariectomized rats / Aya Mostafa Abdellatif Mohamed ; Supervised Mahmoud Mohamed Khattab , Noha Fawzy Hamed

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Aya Mostafa Abdellatif Mohamed

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Material type: Text

TextLanguage: English Publication details: Cairo : Aya Mostafa Abdellatif Mohamed , 2018Description: 139 P. : charts , facsimiles ; 25cmOther title:

تأثير الإستروجين و مقيد لمستقبل الأنجيوتنسين فى ضعف التعرف فى الجرذان مستأصلة المبيض [Added title page title]

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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology Summary: The present study aimed to investigate the possible effects of treatment with telmisartan and 17Ý-estradiol (E2) alone or in combination on Alzheimer{u2019}s disease (AD) like symptoms induced by D-galactose administration to ovariectomized rats. Treatment with telmisartane and E2 alone or in combination improved animals{u2019} behavior assessed by morris water maze and novel object recognition tests, alleviated histopathological alterations and reduced the level of inflammatory biomarkers 2tumor necrosis factor-Ü (TNF-Ü) and interleukin-1Ý (IL-1Ý)3 as well as AD biomarkers 2amyloid beta 1-42 (AÝ1-42) and acetylcholine esterase (AchE)3. This was associated with modulation in renin angiotensin system (RAS) favoring alternative neuroprotective arm (ACE2/ Ang (1-7)/ Mas receptor axis). Moreover, combined therapy produced more pronounced reduction in inflammatory biomarkers as well as AD biomarkers and more modulation of RAS than usage of each drug alone. These findings suggest possible therapeutic options for protection and delay of AD neurotoxicity

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Item type	Current library	Home library	Call number	Copy number	Status	Date due	Barcode
Thesis	قاعة الرسائل الجامعية - الدور الاول	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.08.09.M.Sc.2018.Ay.E (Browse shelf(Opens below))		Not for loan		01010110077744000
CD - Rom	مخـــزن الرســائل الجـــامعية - البدروم	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.08.09.M.Sc.2018.Ay.E (Browse shelf(Opens below))	77744.CD	Not for loan		01020110077744000

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology

The present study aimed to investigate the possible effects of treatment with telmisartan and 17Ý-estradiol (E2) alone or in combination on Alzheimer{u2019}s disease (AD) like symptoms induced by D-galactose administration to ovariectomized rats. Treatment with telmisartane and E2 alone or in combination improved animals{u2019} behavior assessed by morris water maze and novel object recognition tests, alleviated histopathological alterations and reduced the level of inflammatory biomarkers 2tumor necrosis factor-Ü (TNF-Ü) and interleukin-1Ý (IL-1Ý)3 as well as AD biomarkers 2amyloid beta 1-42 (AÝ1-42) and acetylcholine esterase (AchE)3. This was associated with modulation in renin angiotensin system (RAS) favoring alternative neuroprotective arm (ACE2/ Ang (1-7)/ Mas receptor axis). Moreover, combined therapy produced more pronounced reduction in inflammatory biomarkers as well as AD biomarkers and more modulation of RAS than usage of each drug alone. These findings suggest possible therapeutic options for protection and delay of AD neurotoxicity

Issued also as CD

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