Genetic analysis of endoglin pathway components and their possible association with risk of preeclampsia in Egyptian women / (Record no. 72886)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02923cam a2200337 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032328.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 190716s2019 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.01.M.Sc.2019.As.G |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Asmaa Ahmed Ibrahim Elmonier |
| 245 10 - TITLE STATEMENT | |
| Title | Genetic analysis of endoglin pathway components and their possible association with risk of preeclampsia in Egyptian women / |
| Statement of responsibility, etc. | Asmaa Ahmed Ibrahim Elmoniern ; Supervised Amira Abdelmonem Shaheen , Noha Ahmed Elboghdady |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | التحليل الجينى لمكونات مسار الإندوجلين وإمكانية إرتباطهم بخطرالإصابة بتسمم الحمل فى السيدات المصريات |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Asmaa Ahmed Ibrahim Elmonier , |
| Date of publication, distribution, etc. | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 82 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Biochemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Introduction:Preeclampsia(PE)isapregnancy-specifichypertensivediseasewhose etiopathogenesis remains unclear. Objectives: This study was designed to assess association between PE and 3 single nucleotide polymorphisms (SNPs): ENG (G/A) rs11792480, TGFÝR1 (A/C) rs10739778 and TGFÝR2 (G/A) rs6550005, beside the circulating level of soluble endoglin (sENG), oxidative stress biomarkers and nitric oxide (NO) in Egyptian women. Methods: The study included 75 preeclamptic women stratified into 4 clinical subgroups and 50 normotensive pregnant women. Genotyping was performed by real time polymerase chain reaction-TaqMan allelic discrimination. Results: Preeclamptic women showed significantly increased sENG and malondialdehyde (MDA) levels, decreased total antioxidant capacity (TAC), endothelial nitric oxide synthase (eNOS) and NO levels, without change in transforming growth factor beta 1 (TGFÝ1) level versus controls. Moreover, sENG was significantly higher in severe than mild PE and in early- than late-onset PE. Higher MDA and lower TAC and NO levels were observed in severe than mild PE. ENG (G/A) and TGFÝR2 (G/A) showed no association with PE. However, CC genotype of TGFÝR1 (A/C) was more frequent in controls than either PE, early-onset or severe PE revealing a reduced PE risk in CC genotype versus AA or AA+AC. Importantly, patients carrying AA genotype had higher systolic blood pressure (SBP) and MDA with lower TAC level, gestational age (GA) at delivery and birth weight than those carrying CC genotype |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Endoglin |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Polymorphism |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Preeclampsia |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Amira Abdelmonem Shaheen , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Noha Ahmed Elboghdady , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.01.M.Sc.2019.As.G | 01010110078719000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.01.M.Sc.2019.As.G | 01020110078719000 | 22.09.2023 | CD - Rom | 78719.CD |