A study of the effect of Liraglutide, Sitagliptin and Sulfasalazine on experimentally induced inflammatory bowel disease in mice / (Record no. 73820)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03486cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032356.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 190911s2019 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.29.M.Sc.2019.Om.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Omnia Azmy Nabeh Elshiekh |
| 245 12 - TITLE STATEMENT | |
| Title | A study of the effect of Liraglutide, Sitagliptin and Sulfasalazine on experimentally induced inflammatory bowel disease in mice / |
| Statement of responsibility, etc. | Omnia Azmy Nabeh Elshiekh ; Supervised Nawal Elsayed Elgawhary , Magdy Ishak Attallah , Wael Mostafa Mohamed Mostafa |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة تأثير الليراجلوتايد: السيتاجليبتين والسالفاسلازين علي التهاب القولون التقرحي المحدث تجريبيا في الفئران |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Omnia Azmy Nabeh Elshiekh , |
| Date of publication, distribution, etc. | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 112 P. : |
| Other physical details | charts , facimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University -Faculty of Medicine - Department of Pharmacology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Introduction: The most common types of IBD are Crohn{u2019}s disease (CD) and ulcerative colitis (UC). So far, the main therapeutics broadly available to treat IBD are based on suppressing the immune response. But these therapies are unable to reset the intestinal homeostasis and do not directly treat the underlying cause of the chronic inflammation Materials and methods Seventy mice were included in this study and they were divided into 7 group. After fasting for 24 hours and under isoflurane 2% anaethesia, colonic lavage with normal saline was done using a polypropylene trocar cannula inserted through the rectum. Group 1 is a control negative group, while the other six groups received 0.1ml of acetic acid 4% intrarectally that are left for 15 seconds in contact with the colonic tissue to induce colitis followed by colonic lavage with saline. Twenty four hours later group 1(control negative) and group 2(control positive) were left untreated while the other five groups were treated as follow: -Group 3a: Mice in this group received Liraglutide at a starting dose of 0.3mg/kg/day S.C injection, increased to 0.6 mg/kg/day on day 2 of treatment and then 1mg/kg/d from day 3 to day 10 by S.C injection once daily. -Group 3b : Mice in this group received Sitagliptin 100 mg/kg/d orally by oral gavage once daily for 10 days. -Group 3c: Mice in this group received Sulfasalazine in a dose of 100 mg/kg/d orally by oral gavage once daily for 10 days.-Group 3d: Mice in this group received a combination of both drugs (Liraglutide at a starting dose of 0.3 mg/kg/day S.C injection, increased to 0.6 mg/kg/day on day 2 of treatment and then 1mg/kg/d from day 3 to day 10 by S.C injection once daily and Sulfasalazine in a dose of 100 mg/kg/d orally by oral gavage) for 10 days. -Group 3e: Mice in this group received a combination of both drugs (Sitagliptin 100 mg/kg/d orally by oral gavage once daily and Sulfasalazine in a dose of 100 mg/kg/d orally by oral gavage) for 10 days |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Liraglutide |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Sitagliptin |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Sulfasalazine |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Magdy Ishak Attallah , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nawal Elsayed Elgawhary , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wael Mostafa Mohamed Mostafa , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.29.M.Sc.2019.Om.S | 01010110079213000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.29.M.Sc.2019.Om.S | 01020110079213000 | 22.09.2023 | CD - Rom | 79213.CD |