MARC details
| 000 -LEADER |
|---|
| fixed length control field |
02589cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
211133s2021 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.12.21.Ph.D.2021.Sa.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Sara Ibrahim Mohamed |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Efficacy of pyrroloquinoline quinone (PQQ)loaded on nanofibers after experimental spinal cord injury in rats / |
| Statement of responsibility, etc. |
Sara Ibrahim Mohamed ; Supervised Mohamed Ismail Mohamed , Taghride Abdel Rahman , Ahmed Abdellatif Abdelmaged |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
فاعلية البيرولوكينولين كينون المحمول على ألياف نانوية عقب إصابة الحبل الشوكى تجريببا فى الجرذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Sara Ibrahim Mohamed , |
| Date of publication, distribution, etc. |
2021 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
126 P. : |
| Other physical details |
charts , facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Zoology |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
The aim of this study was to investigate the neuroprotective effects of PQQ loaded on coaxial nanofibers following spinal cord injury in adult female Sprague Dawley rats (n = 100). The animals were divided into five groups: control, sham, SCI, unloaded nanofibers, and nanofibers loaded with PQQ.SCI caused a significant increase in the levels of IL-1Ý, IL-6, TNF-Ü, NF-kB, NO, iNOS and MDA. On the other hand, the injury induced a significant decrease in the level of IL-10 and the SOD and CAT activities in injured spinal cord tissue. Treatment of rats post SCI with unloaded nanofibers improved most of the above mentioned biochemical parameters and shifted them toward the sham group values.The treatment of SCI rats with PQQ loaded on coaxial nanofibers ameliorated all the investigated biochemical parameters. PQQ induced a decrease in the levels of IL-1Ý, IL-6, TNF-Ü, NF-kB, NO, iNOS and MDA, while caused an increase in the level of IL-10 and the activities of SOD and CAT in injured spinal cord tissue. However, the present study provides new insight into the anti-inflammatory and anti-oxidative stress mechanisms of PQQ action, so further studies are required to clarify the role of PQQ loaded on coaxial nanofibers in SCI treatment |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Coaxial nanofibers |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
PQQ |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
SCI |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Ahmed Abdellatif Abdelmaged , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mohamed Ismail Mohamed , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Taghride Abdel Rahman , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Shimaa |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
