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Prognosis and outcome of philadelphia chromosome-positive acute lymphoblastic leukemia pediatric patients at the National Cancer Institute in Egypt / by Esraa Samy Abdel- Hameed ; Supervision Prof. Hossam El Zomor, Prof. Ahmed Ibrahim Elhemaly, Prof. Mona El - Ashry.

By: Contributor(s): Material type: TextTextLanguage: English Summary language: English, Arabic Producer: 2024Description: 75 pages : illustrations ; 25 cm. + CDContent type:
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Other title:
  • المستقبل المرضى ونتائج العلاج فى مرضى الأطفال الذين يعانون من سرطان الدم الليمفاوى الحاد الإيجابى لكروموسوم فيلادلفيا فى المعهد القومى للسرطان فى مصر [Added title page title]
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  • Issues also as CD.
Dissertation note: Thesis (M.Sc)-Cairo University, 2024. Summary: The most predominant cancer in the pediatric age category is acute lymphoblastic leukemia (ALL). In Egypt, between 2007 and 2017, a study at Children's Cancer Hospital Egypt-(CCHE) was conducted to assess the incidence and OS of cancer in the hospital, representing about 40-50% of all children of cancer in Egypt. It has been reported that Philadelphia Chromosome translocation is an uncommon cytogenetic abnormality in pediatric patients with ALL accounting for less than 5%. Pediatric patients with Ph+ ALL have been recognized as high to very high risk patients with poor prognosis and outcome when treated previously with intensive chemotherapy alone or followed by allogenic heamatopiotic stem cell transplantation, hence the Innovation era of tyrosine kinase inhibitors (TKIs) has been related to significant favorable outcome in Ph+ ALL pediatric patients when used concurrently with intensive chemotherapy. Therefore, the current retrospective study aimed to validate both prognosis and outcome of pediatric patients with Ph+ ALL through assessment of different clinical and pathological prognostic factors on survival rates as overall survival (OS) and event free survival (EFS). Accordingly Ph+ ALL 27 children their age were ranged from 1-18 years and were recruited from NCI, Egypt, during the period from January 2013 to December 2018 and treated with standard of care protocol, then treatment related toxicities were reported and graded according to Common Terminology Criteria for Adverse Events (CTCAE). The result of the current result after post induction analyses of bone marrow obtained at Day 42 of total XV protocol revealed that: • All patients were in CR morphologically, Twenty (74%) patients were <0.1% MRD (CR) by Flow cytometry while 27% failed to achieve CR. FISH analysis was performed post induction with 56% of the patients had MRD >0.01%, while 44% achieved MRD >0.1%. • Cases failed to achieve complete molecular response with Log Reduction <3.542 were 33% and seventeen patients did not have available molecular log reduction post induction. Post consolidation results revealed: • Patients in CR morphologically were twenty-three (85%), and twenty-three patients achieved MRD <0.01 by flow cytometry. Fourteen (52%) patients achieved negative MRD by FISH analysis. • Post consolidation molecular Log Reduction was <3.5 in 30% of cases while 22% achieved complete molecular response At the end of treatment, Cr was reported in 67%, and sixteen (59%) patients achieved MRD <0.1% by FC while two patients had MRD >0.01. Twenty-six (96.3%) patients received TKIs. Initiation TKI time was during induction in 63% of patients, 30% Post Induction and 3.7% post Consolidation.Summary: أكثر أنواع السرطان السائدة في فئة الأطفال هو لوكيميا ليمفوبلازية حادة (ALL). في مصر، تمت دراسة في مستشفى سرطان الأطفال في مصر (CCHE) بين عامي 2007 و 2017 لتقييم معدل الاحتمال والبقاء على قيد الحياة للسرطان في المستشفى، ممثلة حوالي 40-50٪ من جميع أطفال السرطان في مصر. تم الإبلاغ عن تحول كروموسوم فيلادلفيا كتغير سايتوجيني نادر في المرضى الأطفال الذين يعانون من ALL ويمثل أقل من 5٪. تم التعرف على المرضى الأطفال الذين يعانون من Ph+ ALL على أنهم مرضى بمخاطر عالية إلى مرتفعة جدًا بتوقعات سيئة ونتائج سيئة عند علاجهم مسبقًا بالعلاج الكيميائي المكثف بمفرده أو بعده تليه زرع الخلايا الجذعية الهيماتوبويتية، وبالتالي فإن عصر الابتكار في مثبطات تيروزين كيناز (TKIs) قد ترتبط بنتائج إيجابية ملحوظة في مرضى الأطفال الذين يعانون من Ph+ ALL عند استخدامها بشكل متزامن مع العلاج الكيميائي المكثف. لذلك، كانت الدراسة الاستعادية الحالية تهدف إلى تحقيق توقعات ونتائج المرضى الأطفال الذين يعانون من Ph+ ALL من خلال تقييم عوامل التوقعات السريرية والمرضية المختلفة على معدلات البقاء مثل البقاء الكلي (OS) والبقاء الحر من الأحداث (EFS). وبناءً على ذلك، تم تضمين 27 طفلاً يتراوح عمرهم بين 1-18 عامًا وتم جمعهم من NCI، مصر، خلال الفترة من يناير 2013 إلى ديسمبر 2018 وتم علاجهم بمعايير الرعاية القياسية، ثم تم الإبلاغ عن السموم المتعلقة بالعلاج وتصنيفها وفقًا لمصطلحات الأحداث السلبية المشتركة (CTCAE).
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.19.05.M.Sc.2024.ES.P (Browse shelf(Opens below)) Not for loan 01010110090875000
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Cai01.19.05.M.Sc.2023.Nd.I Infection-related Morbidity in relapsed Acute Lymphoblastic Leukemia Among Pediatric Patients at the National Cancer Institute Cairo University / Cai01.19.05.M.Sc.2023.Pa.C Cardiotoxicity in Pediatric Acute Myeloid Leukemia at the National Cancer Institute / Cai01.19.05.M.Sc.2024.Am.P Pattern of CD8+ T-cell lymphocytes infiltration in wilms tumor in pediatric patients / Cai01.19.05.M.Sc.2024.ES.P Prognosis and outcome of philadelphia chromosome-positive acute lymphoblastic leukemia pediatric patients at the National Cancer Institute in Egypt / Cai01.19.05.M.Sc.2024.Ma.E Expression pattern and prognostic significance of CASP8AP2 in pediatric acute lymphoblastic leukemia at the National Cancer Institute-Egypt / Cai01.19.05.M.Sc.2024.Ma.V. The Value Of Interleukin-6, Pentraxin3 And Procalcitonin Levels In Early Prediction Of Bacteremia And Septic Complications Among Pediatric Cancer Patients With High-Risk Fever And Neutropenia, A Single Institute Prospective: Study At National Cancer Institute-Egypt / Cai01.19.05.M.Sc.2024.Sa.C Clinical pattern of and treatment outcome of Desmoid fibromatosis in paediatric age group, National cancer institute, Cairo university /

Thesis (M.Sc)-Cairo University, 2024.

Bibliography: pages 67-72.

The most predominant cancer in the pediatric age category is acute lymphoblastic leukemia (ALL). In Egypt, between 2007 and 2017, a study at Children's Cancer Hospital Egypt-(CCHE) was conducted to assess the incidence and OS of cancer in the hospital, representing about 40-50% of all children of cancer in Egypt.
It has been reported that Philadelphia Chromosome translocation is an uncommon cytogenetic abnormality in pediatric patients with ALL accounting for less than 5%. Pediatric patients with Ph+ ALL have been recognized as high to very high risk patients with poor prognosis and outcome when treated previously with intensive chemotherapy alone or followed by allogenic heamatopiotic stem cell transplantation, hence the Innovation era of tyrosine kinase inhibitors (TKIs) has been related to significant favorable outcome in Ph+ ALL pediatric patients when used concurrently with intensive chemotherapy.
Therefore, the current retrospective study aimed to validate both prognosis and outcome of pediatric patients with Ph+ ALL through assessment of different clinical and pathological prognostic factors on survival rates as overall survival (OS) and event free survival (EFS).
Accordingly Ph+ ALL 27 children their age were ranged from 1-18 years and were recruited from NCI, Egypt, during the period from January 2013 to December 2018 and treated with standard of care protocol, then treatment related toxicities were reported and graded according to Common Terminology Criteria for Adverse Events (CTCAE).
The result of the current result after post induction analyses of bone marrow obtained at Day 42 of total XV protocol revealed that:
• All patients were in CR morphologically, Twenty (74%) patients were <0.1% MRD (CR) by Flow cytometry while 27% failed to achieve CR. FISH analysis was performed post induction with 56% of the patients had MRD >0.01%, while 44% achieved MRD >0.1%.
• Cases failed to achieve complete molecular response with Log Reduction <3.542 were 33% and seventeen patients did not have available molecular log reduction post induction.
Post consolidation results revealed:
• Patients in CR morphologically were twenty-three (85%), and twenty-three patients achieved MRD <0.01 by flow cytometry. Fourteen (52%) patients achieved negative MRD by FISH analysis.
• Post consolidation molecular Log Reduction was <3.5 in 30% of cases while 22% achieved complete molecular response
At the end of treatment, Cr was reported in 67%, and sixteen (59%) patients achieved MRD <0.1% by FC while two patients had MRD >0.01.
Twenty-six (96.3%) patients received TKIs. Initiation TKI time was during induction in 63% of patients, 30% Post Induction and 3.7% post Consolidation.

أكثر أنواع السرطان السائدة في فئة الأطفال هو لوكيميا ليمفوبلازية حادة (ALL). في مصر، تمت دراسة في مستشفى سرطان الأطفال في مصر (CCHE) بين عامي 2007 و 2017 لتقييم معدل الاحتمال والبقاء على قيد الحياة للسرطان في المستشفى، ممثلة حوالي 40-50٪ من جميع أطفال السرطان في مصر.
تم الإبلاغ عن تحول كروموسوم فيلادلفيا كتغير سايتوجيني نادر في المرضى الأطفال الذين يعانون من ALL ويمثل أقل من 5٪. تم التعرف على المرضى الأطفال الذين يعانون من Ph+ ALL على أنهم مرضى بمخاطر عالية إلى مرتفعة جدًا بتوقعات سيئة ونتائج سيئة عند علاجهم مسبقًا بالعلاج الكيميائي المكثف بمفرده أو بعده تليه زرع الخلايا الجذعية الهيماتوبويتية، وبالتالي فإن عصر الابتكار في مثبطات تيروزين كيناز (TKIs) قد ترتبط بنتائج إيجابية ملحوظة في مرضى الأطفال الذين يعانون من Ph+ ALL عند استخدامها بشكل متزامن مع العلاج الكيميائي المكثف.
لذلك، كانت الدراسة الاستعادية الحالية تهدف إلى تحقيق توقعات ونتائج المرضى الأطفال الذين يعانون من Ph+ ALL من خلال تقييم عوامل التوقعات السريرية والمرضية المختلفة على معدلات البقاء مثل البقاء الكلي (OS) والبقاء الحر من الأحداث (EFS).
وبناءً على ذلك، تم تضمين 27 طفلاً يتراوح عمرهم بين 1-18 عامًا وتم جمعهم من NCI، مصر، خلال الفترة من يناير 2013 إلى ديسمبر 2018 وتم علاجهم بمعايير الرعاية القياسية، ثم تم الإبلاغ عن السموم المتعلقة بالعلاج وتصنيفها وفقًا لمصطلحات الأحداث السلبية المشتركة (CTCAE).

Issues also as CD.

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