Design and synthesis of novel Ý - carboline derivatives as phosphodiesterase 5 inhibitors and anticancer agents / Nancy Maher Riad Girgis ; Supervised Ashraf H. Abadi

By:

Nancy Maher Riad Girgis

Contributor(s):

Ashraf H. Abadi []

Material type: Text

TextLanguage: English Publication details: Cairo : Nancy Maher Riad Girgis , 2010Description: 138Leaves : charts , facsimiles ; 30cmOther title:

تصميم وتشييد مشتقات جديدة من البيتا كاربولين مثبطات لإنزيم فوسفودايستراز 5 ومضادات للسرطان [Added title page title]

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Dissertation note: Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical chemistry Summary: Tadalfil is one of the widely marketed medications for the treatment of male erectile dysfunction . Despite its potency and efficacy it is still not free from side effects and its cross reactivity with other phosphodiesterases particularly PDE11 is still a point of question . Moreover many recent studies have showed that PDE5 and other PDEs are over - expressed in malignant tumor cells thus inhibiting PDEs action may be related to anticancer and apoptotic activities

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Item type	Current library	Home library	Call number	Status	Barcode
Thesis	قاعة الثقاقات الاجنبية - الدور الثالث	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.34.M.Sc.2010.Na.D (Browse shelf(Opens below))	Not for loan	01010110060177000

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Previous	Cai01.34.M.Sc.2010.Mo.N Novel modulators of serotonin receptor 5HT₃ and related prokaryotic receptor /	Cai01.34.M.Sc.2010.Mo.R Representing time of navigation and modification in spatial hypertext /	Cai01.34.M.Sc.2010.Na.A The anti - inflammatory and analgesic effects of thymoquinone /	Cai01.34.M.Sc.2010.Na.D Design and synthesis of novel Ý - carboline derivatives as phosphodiesterase 5 inhibitors and anticancer agents /	Cai01.34.M.Sc.2010.Na.M Multi - modal perception as grounded focused belief revision /	Cai01.34.M.Sc.2010.Ne.E Extraction of reverberation parameters from spatial information /	Cai01.34.M.Sc.2010.No.A Assessment of the efficacy of polyclonal intravenous immunoglobulin G preparation on Egyptian clinical isolates of methicillin resistant staphylococcus aureus (MRSA) /	Next

Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical chemistry

Tadalfil is one of the widely marketed medications for the treatment of male erectile dysfunction . Despite its potency and efficacy it is still not free from side effects and its cross reactivity with other phosphodiesterases particularly PDE11 is still a point of question . Moreover many recent studies have showed that PDE5 and other PDEs are over - expressed in malignant tumor cells thus inhibiting PDEs action may be related to anticancer and apoptotic activities

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