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Synthesis and pharmacological evaluation of novel N - acyl (phenylpropylamine) analogs as MT₂⁻ selective ligands for melatonin receptors / Norhan Samir Mahfouz ; Supervised Darius P. Zlotos

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Norhan Samir Mahfouz , 2012Description: 125 Leaves ; 30cmOnline resources: Dissertation note: Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry Summary: Pharmacological actions of the neurohormone melatonin are mediated by the activation of the two G - protein coupled receptors MT₁ and MT₂. An accurate characterisation of melatonin receptor - mediated functions requires MT₁ and MT₂⁻ selective ligands while pronounced MT₁ selectivity is still a challenge, many MT₂⁻ selective ligands, exemplified by compound 14c, have been reported, most of them behaving as antagonists
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Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry

Pharmacological actions of the neurohormone melatonin are mediated by the activation of the two G - protein coupled receptors MT₁ and MT₂. An accurate characterisation of melatonin receptor - mediated functions requires MT₁ and MT₂⁻ selective ligands while pronounced MT₁ selectivity is still a challenge, many MT₂⁻ selective ligands, exemplified by compound 14c, have been reported, most of them behaving as antagonists

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