Expression of sirtuin 1 and its relation to tumor necrosis factor - alpha in psoriatic plaques / Aya Magdi Ibrahim Alorbani ; Supervised Hoda Mohamed Hussein Rasheed , Mohamed Hussein Medhat Elkomy , Olfat Gamil Shaker
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TextLanguage: English Publication details: Cairo : Aya Magdi Ibrahim Alorbani , 2014Description: 121 Leaves : facsimiles ; 25cmOther title: - إكتشاف السرتوين {u٠٦ئ١} و علاقته بعامل نخر الأورام ألفا في مرض الصدفية [Added title page title]
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Thesis
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قاعة الرسائل الجامعية - الدور الاول | المكتبة المركزبة الجديدة - جامعة القاهرة | Cai01.11.10.M.Sc.2014.Ay.E (Browse shelf(Opens below)) | Not for loan | 01010110063256000 | ||
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مخـــزن الرســائل الجـــامعية - البدروم | المكتبة المركزبة الجديدة - جامعة القاهرة | Cai01.11.10.M.Sc.2014.Ay.E (Browse shelf(Opens below)) | 63256.CD | Not for loan | 01020110063256000 |
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Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Dermatology and Venerology
Although it is now considered a prototypic Th1/Th17-mediated disease, several gaps still exist in our understanding of the pathogenesis of psoriasis. Sirtuins, a family of seven proteins that have generated huge interest in several fields including dermatology, have been proposed to contribute to the development of inflammatory and hyperproliferative disease. It has been proposed that changes in Sirtuin 1 (SIRT1), through its effect on pro-inflammatory cytokines such as Tumor Necrosis Factor-alpha (TNF-Ü), may contribute to the development of the psoriatic plaque.
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