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Studies on the biodistribution and antioxidant activity of some labelled agents / Fawzy Abdulmegeed Mohamed Marzouk ; Supervised Maged M. A. Barakat , Elsayed Abdelghany Elsayed , Mohammed Hussain Awwad

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Fawzy Abdulmegeed Mohamed Marzouk , 2014Description: 173 P. ; 25cmOther title:
  • دراسات على التوزيع البيولوجى للمركبات المرقمة إشعاعيا و النشاط المضاد للأكسدة لبعض المركبات المخلبية [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Biochemistry Summary: Chelating agents such as carnosine and DMSA can be used in nuclear medicine and biochemical studies. Carnosine was labelled by using tin chloride in presence of glucose as reducing agent and resultant 99mTc - carnosine showed some tumour selectivity. 99mTc (V) DMSA were prepared in high purity by simple decreasing tin content and its biodistribution showed high tumor selectivity. Also the present study investigated that chelating agents impart strong antioxidant activity through inhibition of metal catalyzed fenton reaction. Studied antioxidant parameters such as SOD, MDA, and reduced glutathione and PCR {u2013} RFLP biomarkers as extracellular, tissue and genomic model for measuring oxidative stress showed probable higher antioxidant activity of carnosine than DMSA and maximum protection with dual action of both chelating agent
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.01.Ph.D.2014.Fa.S (Browse shelf(Opens below)) Not for loan 01010110063895000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.01.Ph.D.2014.Fa.S (Browse shelf(Opens below)) 63895.CD Not for loan 01020110063895000

Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Biochemistry

Chelating agents such as carnosine and DMSA can be used in nuclear medicine and biochemical studies. Carnosine was labelled by using tin chloride in presence of glucose as reducing agent and resultant 99mTc - carnosine showed some tumour selectivity. 99mTc (V) DMSA were prepared in high purity by simple decreasing tin content and its biodistribution showed high tumor selectivity. Also the present study investigated that chelating agents impart strong antioxidant activity through inhibition of metal catalyzed fenton reaction. Studied antioxidant parameters such as SOD, MDA, and reduced glutathione and PCR {u2013} RFLP biomarkers as extracellular, tissue and genomic model for measuring oxidative stress showed probable higher antioxidant activity of carnosine than DMSA and maximum protection with dual action of both chelating agent

Issued also as CD

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